| Host: |
Rabbit |
| Applications: |
IHC/WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-KCNJ4 (Cytoplasmic Domain) is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Lyophilised |
| Purification: |
IgG purified |
| Dilution Range: |
IHC, WB. A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Storage Instruction: |
Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: |
KCNJ4 |
| Gene ID: |
3761 |
| Uniprot ID: |
KCNJ4_HUMAN |
| Immunogen Region: |
Cytoplasmic Domain |
| Specificity: |
Specific for KCNJ4. |
| Immunogen: |
A synthetic peptide from the cytoplasmic domain of human KCNJ4 (Kir2.3, HIRK2, HRK1, HIR) conjugated to an immunogenic carrier protein was used as the antigen. The antigen shares 91% identity with rat and mouse sequences. |
| Function | Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium.as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium. |
| Protein Name | Inward Rectifier Potassium Channel 4Hirk2Hrk1Hippocampal Inward RectifierHirInward Rectifier K(+ Channel Kir2.3Irk-3Potassium Channel - Inwardly Rectifying Subfamily J Member 4 |
| Database Links | Reactome: R-HSA-1296041Reactome: R-HSA-1296053Reactome: R-HSA-5576886Reactome: R-HSA-997272 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinPostsynaptic Cell MembraneCytoplasmic Vesicle MembraneTax1bp3 Binding Promotes Dissociation Of Kcnj4 From Lin7 Famaly Members And Kcnj4 Internalization |
| Alternative Antibody Names | Anti-Inward Rectifier Potassium Channel 4 antibodyAnti-Hirk2 antibodyAnti-Hrk1 antibodyAnti-Hippocampal Inward Rectifier antibodyAnti-Hir antibodyAnti-Inward Rectifier K(+ Channel Kir2.3 antibodyAnti-Irk-3 antibodyAnti-Potassium Channel - Inwardly Rectifying Subfamily J Member 4 antibodyAnti-KCNJ4 antibodyAnti-IRK3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
