Anti-KCNJ2 antibody (50-150 aa) (STJ11106018)

SKU:
STJ11106018
€140.63 - €655.63
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Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:2000
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Gene Symbol: KCNJ2
Gene ID: 3759
Uniprot ID: KCNJ2_HUMAN
Immunogen Region: 50-150 aa
Specificity: A synthetic peptide corresponding to a sequence within amino acids 50-150 of human KCNJ2 (NP_000882.1).
Immunogen Sequence: KDGHCNVQFINVGEKGQRYL ADIFTTCVDIRWRWMLVIFC LAFVLSWLFFGCVFWLIALL HGDLDASKEGKACVSEVNSF TAAFLFSIETQTTIGYGFRC V
Tissue Specificity Heart, brain, placenta, lung, skeletal muscle, and kidney. Diffusely distributed throughout the brain.
Post Translational Modifications S-nitrosylation increases the open probability and inward rectifying currents.
Function Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium.as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium or cesium. Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues.
Protein Name Inward Rectifier Potassium Channel 2
Cardiac Inward Rectifier Potassium Channel
Inward Rectifier K(+ Channel Kir2.1
Irk-1
Hirk1
Potassium Channel - Inwardly Rectifying Subfamily J Member 2
Database Links Reactome: R-HSA-1296041
Reactome: R-HSA-1296053
Reactome: R-HSA-5576886
Reactome: R-HSA-9729555
Reactome: R-HSA-997272
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Alternative Antibody Names Anti-Inward Rectifier Potassium Channel 2 antibody
Anti-Cardiac Inward Rectifier Potassium Channel antibody
Anti-Inward Rectifier K(+ Channel Kir2.1 antibody
Anti-Irk-1 antibody
Anti-Hirk1 antibody
Anti-Potassium Channel - Inwardly Rectifying Subfamily J Member 2 antibody
Anti-KCNJ2 antibody
Anti-IRK1 antibody

Information sourced from Uniprot.org