Anti-KCNJ13 antibody (STJ190913)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from part of the human protein
General Information
| Short Description | Rabbit polyclonal anti-Inward rectifier potassium channel 13 channel Kir7.1 for use in WB and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | KCNJ13 |
| Gene ID | 3769 |
| Uniprot ID | KCJ13_HUMAN |
| Immunogen | Synthesized peptide derived from part of the human protein |
| Specificity | IRK13 Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Post Translational Modifications | Phosphorylation at Ser-201 by PKC strongly inhibits ionic currents, while phosphorylation at Ser-287 by PKA increases them. |
| Function | Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium.as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ13 has a very low single channel conductance, low sensitivity to block by external barium and cesium, and no dependence of its inward rectification properties on the internal blocking particle magnesium. |
| Protein Name | Inward Rectifier Potassium Channel 13Inward Rectifier K(+ Channel Kir7.1Potassium Channel - Inwardly Rectifying Subfamily J Member 13 |
| Database Links | |
| Cellular Localisation | MembraneMulti-Pass Membrane ProteinCell MembraneLocalized At The Retinal Pigmented Epithelium (Rpe) Apical Microvilli |
| Alternative Antibody Names | Anti-Inward Rectifier Potassium Channel 13 antibodyAnti-Inward Rectifier K(+ Channel Kir7.1 antibodyAnti-Potassium Channel - Inwardly Rectifying Subfamily J Member 13 antibodyAnti-KCNJ13 antibody |
Information sourced from Uniprot.org