Anti-KCNJ13 antibody (2-50 aa) (STJ13101306)

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STJ13101306-100
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Host: Rabbit
Applications: IHC/WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit polyclonal antibody anti-KCNJ13 (2-50 aa) is suitable for use in Immunohistochemistry and Western Blot research applications.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Lyophilised
Purification: IgG purified
Dilution Range: IHC, WB (confirmed by recombinant protein). A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Storage Instruction: Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Gene Symbol: KCNJ13
Gene ID: 3769
Uniprot ID: KCJ13_HUMAN
Immunogen Region: 2-50 aa
Specificity: Specific for KCNJ13.
Immunogen: A synthetic peptide from aa region 2-50 of human KCNJ13 conjugated to blue carrier protein was used as the antigen. The peptide shares 95% identity with mouse and rat sequences.
Post Translational Modifications Phosphorylation at Ser-201 by PKC strongly inhibits ionic currents, while phosphorylation at Ser-287 by PKA increases them.
Function Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium.as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ13 has a very low single channel conductance, low sensitivity to block by external barium and cesium, and no dependence of its inward rectification properties on the internal blocking particle magnesium.
Protein Name Inward Rectifier Potassium Channel 13
Inward Rectifier K(+ Channel Kir7.1
Potassium Channel - Inwardly Rectifying Subfamily J Member 13
Cellular Localisation Membrane
Multi-Pass Membrane Protein
Alternative Antibody Names Anti-Inward Rectifier Potassium Channel 13 antibody
Anti-Inward Rectifier K(+ Channel Kir7.1 antibody
Anti-Potassium Channel - Inwardly Rectifying Subfamily J Member 13 antibody
Anti-KCNJ13 antibody

Information sourced from Uniprot.org

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