Anti-KCNJ11 antibody (190-239 aa) (STJ93844)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human Kir6.2 at the amino acid range 190-239
General Information
| Short Description | Rabbit polyclonal anti-ATP-sensitive inward rectifier potassium channel 11 channel Kir6.2 (190-239 aa) for use in WB, IHC, IF and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300IF 1:200-1:1000ELISA 1:10000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | KCNJ11 |
| Gene ID | 3767 |
| Uniprot ID | KCJ11_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human Kir6.2 at the amino acid range 190-239 |
| Immunogen Region | 190-239 aa |
| Specificity | KIR6.2 Polyclonal Antibody detects endogenous levels of KIR6.2 protein. |
Additional Info
| Function | Inward rectifier potassium channel that forms the pore of ATP-sensitive potassium channels (KATP), regulating potassium permeability as a function of cytoplasmic ATP and ADP concentrations in many different cells. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium.as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium. In pancreatic cells, it forms KATP channels with ABCC8/SUR1. Can form cardiac and smooth muscle-type KATP channels with ABCC9. |
| Protein Name | Atp-Sensitive Inward Rectifier Potassium Channel 11IkatpInward Rectifier K(+ Channel Kir6.2Potassium Channel - Inwardly Rectifying Subfamily J Member 11 |
| Database Links | Reactome: R-HSA-1296025Reactome: R-HSA-382556Reactome: R-HSA-422356Reactome: R-HSA-5578775Reactome: R-HSA-5678420Reactome: R-HSA-5683177 |
| Cellular Localisation | MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Atp-Sensitive Inward Rectifier Potassium Channel 11 antibodyAnti-Ikatp antibodyAnti-Inward Rectifier K(+ Channel Kir6.2 antibodyAnti-Potassium Channel - Inwardly Rectifying Subfamily J Member 11 antibodyAnti-KCNJ11 antibody |
Information sourced from Uniprot.org