Immunofluorescence analysis of A549 cells, using ROMK/Kir1.1 Antibody. The picture on the right is blocked with the synthesized peptide.

Anti-KCNJ1 antibody (11-60 aa) (STJ95529)

SKU:
STJ95529
£48.00 - £252.00
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Covered by St John's Laboratory Guarantee

Host: Rabbit
Applications: WB/IHC
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit polyclonal antibody anti-ATP-sensitive inward rectifier potassium channel 1 channel Kir1.1 (11-60 aa) is suitable for use in Western Blot and Immunohistochemistry research applications.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
IHC-P 1:50-300
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: KCNJ1
Gene ID: 3758
Uniprot ID: KCNJ1_HUMAN
Immunogen Region: 11-60 aa
Specificity: ROM-K Polyclonal Antibody detects endogenous levels of ROM-K protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the human ROMK/Kir1.1 at the amino acid range 11-60
Post Translational Modifications Phosphorylation at Ser-44 by SGK1 is necessary for its expression at the cell membrane.
Function Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium.as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This channel is activated by internal ATP and can be blocked by external barium. In the kidney, probably plays a major role in potassium homeostasis.
Protein Name Atp-Sensitive Inward Rectifier Potassium Channel 1
Atp-Regulated Potassium Channel Rom-K
Inward Rectifier K(+ Channel Kir1.1
Potassium Channel - Inwardly Rectifying Subfamily J Member 1
Database Links Reactome: R-HSA-1296067
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Phosphorylation At Ser-44 By Sgk1 Is Necessary For Its Expression At The Cell Membrane
Alternative Antibody Names Anti-Atp-Sensitive Inward Rectifier Potassium Channel 1 antibody
Anti-Atp-Regulated Potassium Channel Rom-K antibody
Anti-Inward Rectifier K(+ Channel Kir1.1 antibody
Anti-Potassium Channel - Inwardly Rectifying Subfamily J Member 1 antibody
Anti-KCNJ1 antibody
Anti-ROMK1 antibody

Information sourced from Uniprot.org

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