| Host: |
Rabbit |
| Applications: |
IHC/WB |
| Reactivity: |
Mouse/Rat/Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-KCNH2 (1120-1162 aa) is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Lyophilised |
| Purification: |
IgG purified |
| Dilution Range: |
IHC, WB. A dilution of 1:1000 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Storage Instruction: |
Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: |
KCNH2 |
| Gene ID: |
3757 |
| Uniprot ID: |
KCNH2_HUMAN |
| Immunogen Region: |
1120-1162 aa |
| Specificity: |
Specific for KCNS2. |
| Immunogen: |
A synthetic peptide from aa region 1120-1162 of mouse KCNH2 conjugated to blue carrier protein was used as the antigen. The peptide is homologous in rat and human. |
| Post Translational Modifications | Phosphorylated on serine and threonine residues. Phosphorylation by PKA inhibits ion conduction. |
| Function | Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Characterized by unusual gating kinetics by producing relatively small outward currents during membrane depolarization and large inward currents during subsequent repolarization which reflect a rapid inactivation during depolarization and quick recovery from inactivation but slow deactivation (closing) during repolarization. Channel properties are modulated by cAMP and subunit assembly. Forms a stable complex with KCNE1 or KCNE2, and that this heteromultimerization regulates inward rectifier potassium channel activity. Isoform A-USO: Has no inward rectifier potassium channel activity by itself, but modulates channel characteristics by forming heterotetramers with other isoforms which are retained intracellularly and undergo ubiquitin-dependent degradation. Isoform B-USO: Has no inward rectifier potassium channel activity by itself, but modulates channel characteristics by forming heterotetramers with other isoforms which are retained intracellularly and undergo ubiquitin-dependent degradation. |
| Protein Name | Voltage-Gated Inwardly Rectifying Potassium Channel Kcnh2Eag HomologEther-A-Go-Go-Related Gene Potassium Channel 1Erg-1Eag-Related Protein 1Ether-A-Go-Go-Related Protein 1H-ErgHerg-1Herg1Potassium Voltage-Gated Channel Subfamily H Member 2Voltage-Gated Potassium Channel Subunit Kv11.1 |
| Database Links | Reactome: R-HSA-1296072Reactome: R-HSA-5576890 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Voltage-Gated Inwardly Rectifying Potassium Channel Kcnh2 antibodyAnti-Eag Homolog antibodyAnti-Ether-A-Go-Go-Related Gene Potassium Channel 1 antibodyAnti-Erg-1 antibodyAnti-Eag-Related Protein 1 antibodyAnti-Ether-A-Go-Go-Related Protein 1 antibodyAnti-H-Erg antibodyAnti-Herg-1 antibodyAnti-Herg1 antibodyAnti-Potassium Voltage-Gated Channel Subfamily H Member 2 antibodyAnti-Voltage-Gated Potassium Channel Subunit Kv11.1 antibodyAnti-KCNH2 antibodyAnti-ERG antibodyAnti-ERG1 antibodyAnti-HERG antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
