| Host: |
Rabbit |
| Applications: |
WB/ELISA/IHC |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Potassium voltage-gated channel subfamily H member 1 (720-769 aa) is suitable for use in Western Blot, ELISA and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000IHC-P 1:50-300ELISA 2000-20000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
KCNH1 |
| Gene ID: |
3756 |
| Uniprot ID: |
KCNH1_HUMAN |
| Immunogen Region: |
720-769 aa |
| Specificity: |
KCNH1 Polyclonal Antibody detects endogenous levels of KCNH1 protein. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from the human KCNH1 at the amino acid range 720-769 |
| Post Translational Modifications | Channel activity is regulated via tyrosine phosphorylation/dephosphorylation by SRC and PTPN6. |
| Function | Pore-forming (alpha) subunit of a voltage-gated delayed rectifier potassium channel that mediates outward-rectifying potassium currents which, on depolarization, reaches a steady-state level and do not inactivate. The activation kinetics depend on the prepulse potential and external divalent cation concentration. With negative prepulses, the current activation is delayed and slowed down several fold, whereas more positive prepulses speed up activation. The time course of activation is biphasic with a fast and a slowly activating current component. Activates at more positive membrane potentials and exhibit a steeper activation curve. Channel properties are modulated by subunit assembly. Mediates IK(NI) current in myoblasts. Involved in the regulation of cell proliferation and differentiation, in particular adipogenic and osteogenic differentiation in bone marrow-derived mesenchymal stem cells (MSCs). |
| Protein Name | Voltage-Gated Delayed Rectifier Potassium Channel Kcnh1Ether-A-Go-Go Potassium Channel 1Eag Channel 1H-EagHeag1Potassium Voltage-Gated Channel Subfamily H Member 1Voltage-Gated Potassium Channel Subunit Kv10.1 |
| Database Links | Reactome: R-HSA-1296072 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinNucleus Inner MembraneCell ProjectionDendriteAxonPresynaptic Cell MembranePerikaryonPostsynaptic Density MembraneEarly Endosome MembranePerinuclear Kcnh1 Is Located To Npc-Free Islands |
| Alternative Antibody Names | Anti-Voltage-Gated Delayed Rectifier Potassium Channel Kcnh1 antibodyAnti-Ether-A-Go-Go Potassium Channel 1 antibodyAnti-Eag Channel 1 antibodyAnti-H-Eag antibodyAnti-Heag1 antibodyAnti-Potassium Voltage-Gated Channel Subfamily H Member 1 antibodyAnti-Voltage-Gated Potassium Channel Subunit Kv10.1 antibodyAnti-KCNH1 antibodyAnti-EAG antibodyAnti-EAG1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
