| Host: |
Rabbit |
| Applications: |
WB/IHC/IF/ELISA |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Potassium voltage-gated channel subfamily D member 1 (558-607 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-1:2000IHC 1:100-1:300ELISA 1:20000IF 1:50-200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
KCND1 |
| Gene ID: |
3750 |
| Uniprot ID: |
KCND1_HUMAN |
| Immunogen Region: |
558-607 aa |
| Specificity: |
KV4.1 Polyclonal Antibody detects endogenous levels of KV4.1 protein. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from the human KCND1 at the amino acid range 558-607 |
| Function | A-type voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes in the brain. Mediates A-type current I(SA) in suprachiasmatic nucleus (SCN) neurons. Exhibits a low-threshold A-type current with a hyperpolarized steady-state inactivation midpoint and the recovery process was steeply voltage-dependent, with recovery being markedly faster at more negative potentials. May regulates repetitive firing rates in the suprachiasmatic nucleus (SCN) neurons and circadian rhythms in neuronal excitability and behavior. Contributes to the regulation of the circadian rhythm of action potential firing in suprachiasmatic nucleus neurons, which regulates the circadian rhythm of locomotor activity. The regulatory subunit KCNIP1 modulates the kinetics of channel inactivation, increases the current amplitudes and accelerates recovery from inactivation, shifts activation in a depolarizing direction. The regulatory subunit DPP10 decreases the voltage sensitivity of the inactivation channel gating. |
| Protein Name | A-Type Voltage-Gated Potassium Channel Kcnd1Potassium Voltage-Gated Channel Subfamily D Member 1Shal-Type Potassium Channel Kcnd1Voltage-Gated Potassium Channel Subunit Kv4.1 |
| Database Links | Reactome: R-HSA-1296072Reactome: R-HSA-5576894 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-A-Type Voltage-Gated Potassium Channel Kcnd1 antibodyAnti-Potassium Voltage-Gated Channel Subfamily D Member 1 antibodyAnti-Shal-Type Potassium Channel Kcnd1 antibodyAnti-Voltage-Gated Potassium Channel Subunit Kv4.1 antibodyAnti-KCND1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
