| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
KCND1 |
| Gene ID: |
3750 |
| Uniprot ID: |
KCND1_HUMAN |
| Immunogen Region: |
488-647 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 488-647 of human KCND1 (NP_004970.3). |
| Immunogen Sequence: |
TTCHEFTDELTFSEALGAVS PGGRTSRSTSVSSQPVGPGS LLSSCCPRRAKRRAIRLANS TASVSRGSMQELDMLAGLRR SHAPQSRSSLNAKPHDSLDL NCDSRDFVAAIISIPTPPAN TPDESQPSSPGGGGRAGSTL RNSSLGTPCLFPETVKISSL |
| Tissue Specificity | Widely expressed. Highly expressed in brain, in particular in cerebellum and thalamus.detected at lower levels in the other parts of the brain. |
| Function | A-type voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes in the brain. Mediates A-type current I(SA) in suprachiasmatic nucleus (SCN) neurons. Exhibits a low-threshold A-type current with a hyperpolarized steady-state inactivation midpoint and the recovery process was steeply voltage-dependent, with recovery being markedly faster at more negative potentials. May regulates repetitive firing rates in the suprachiasmatic nucleus (SCN) neurons and circadian rhythms in neuronal excitability and behavior. Contributes to the regulation of the circadian rhythm of action potential firing in suprachiasmatic nucleus neurons, which regulates the circadian rhythm of locomotor activity. The regulatory subunit KCNIP1 modulates the kinetics of channel inactivation, increases the current amplitudes and accelerates recovery from inactivation, shifts activation in a depolarizing direction. The regulatory subunit DPP10 decreases the voltage sensitivity of the inactivation channel gating. |
| Protein Name | A-Type Voltage-Gated Potassium Channel Kcnd1Potassium Voltage-Gated Channel Subfamily D Member 1Shal-Type Potassium Channel Kcnd1Voltage-Gated Potassium Channel Subunit Kv4.1 |
| Database Links | Reactome: R-HSA-1296072Reactome: R-HSA-5576894 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-A-Type Voltage-Gated Potassium Channel Kcnd1 antibodyAnti-Potassium Voltage-Gated Channel Subfamily D Member 1 antibodyAnti-Shal-Type Potassium Channel Kcnd1 antibodyAnti-Voltage-Gated Potassium Channel Subunit Kv4.1 antibodyAnti-KCND1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
