| Host: |
Rabbit |
| Applications: |
IHC/WB |
| Reactivity: |
Human/Rat/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-KCNC2 (C-Term) is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Lyophilised |
| Purification: |
IgG purified |
| Dilution Range: |
IHC, WB. A dilution of 1:200 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Storage Instruction: |
Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: |
KCNC2 |
| Gene ID: |
3747 |
| Uniprot ID: |
KCNC2_HUMAN |
| Immunogen Region: |
C-Term |
| Specificity: |
Specific for KCNC2. |
| Immunogen: |
A synthetic peptide from c-terminal region of human KCNC2 (Kv3.2) conjugated to an immunogenic carrier protein was used as the antigen. |
| Function | Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain. Contributes to the regulation of the fast action potential repolarization and in sustained high-frequency firing in neurons of the central nervous system. Homotetramer channels mediate delayed-rectifier voltage-dependent potassium currents that activate rapidly at high-threshold voltages and inactivate slowly. Forms tetrameric channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (Probable). Can form functional homotetrameric and heterotetrameric channels that contain variable proportions of KCNC1, and possibly other family members as well.channel properties depend on the type of alpha subunits that are part of the channel. Channel properties may be modulated either by the association with ancillary subunits, such as KCNE1, KCNE2 or KCNE3 or indirectly by nitric oxide (NO) through a cGMP- and PKG-mediated signaling cascade, slowing channel activation and deactivation of delayed rectifier potassium channels. Contributes to fire sustained trains of very brief action potentials at high frequency in retinal ganglion cells, thalamocortical and suprachiasmatic nucleus (SCN) neurons and in hippocampal and neocortical interneurons. Sustained maximal action potential firing frequency in inhibitory hippocampal interneurons is negatively modulated by histamine H2 receptor activation in a cAMP- and protein kinase (PKA) phosphorylation-dependent manner. Plays a role in maintaining the fidelity of synaptic transmission in neocortical GABAergic interneurons by generating action potential (AP) repolarization at nerve terminals, thus reducing spike-evoked calcium influx and GABA neurotransmitter release. Required for long-range synchronization of gamma oscillations over distance in the neocortex. Contributes to the modulation of the circadian rhythm of spontaneous action potential firing in suprachiasmatic nucleus (SCN) neurons in a light-dependent manner. |
| Protein Name | Voltage-Gated Potassium Channel Kcnc2Potassium Voltage-Gated Channel Subfamily C Member 2Shaw-Like Potassium ChannelVoltage-Gated Potassium Channel Kv3.2 |
| Database Links | Reactome: R-HSA-1296072Reactome: R-HSA-381676 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinMembranePerikaryonCell ProjectionAxonDendritePostsynaptic Cell MembranePresynaptic Cell MembraneSynapseSynaptosomeApical Cell MembraneBasolateral Cell MembraneColocalizes With Parvalbumin In Globus Pallidus NeuronsLocalizes In Thalamocortical Axons And SynapsesLocalizes On The Surface Of Cell SomataProximal Dendrites And Axonal MembranesAlso Detected Throughout The NeuropilLocalized In Starburst Cell Somata And Proximal Dendrite ProcessesColocalized With Gaba In Presynaptic TerminalsClustered In Patches In Somatic And Proximal Dendritic Membrane As Well As In Axons And Presnypatic Terminals Of Gabaergic InterneuronsSome Of These Patches Are Found Near Postsynaptic Sites |
| Alternative Antibody Names | Anti-Voltage-Gated Potassium Channel Kcnc2 antibodyAnti-Potassium Voltage-Gated Channel Subfamily C Member 2 antibodyAnti-Shaw-Like Potassium Channel antibodyAnti-Voltage-Gated Potassium Channel Kv3.2 antibodyAnti-KCNC2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
