| Tissue Specificity | Expressed in pyramidal neurons of the cerebral cortex (at protein level). In the brain, the greatest density occurs in the olfactory bulb, followed by the cerebral cortex, hippocampus, and cerebellum. In peripheral tissues it is most prominent in whole tongue epithelium and circumvallate papillae. |
| Post Translational Modifications | Phosphorylated. Phosphorylation at Ser-608 of the FFAT motif activates interaction with MOSPD2, VAPA and VAPB. |
| Function | Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and smooth muscle cells. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient. Homotetrameric channels mediate a delayed-rectifier voltage-dependent outward potassium current that display rapid activation and slow inactivation in response to membrane depolarization. Can form functional homotetrameric and heterotetrameric channels that contain variable proportions of KCNB1.channel properties depend on the type of alpha subunits that are part of the channel. Can also form functional heterotetrameric channels with other alpha subunits that are non-conducting when expressed alone, such as KCNS1 and KCNS2, creating a functionally diverse range of channel complexes. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Contributes to the delayed-rectifier voltage-gated potassium current in cortical pyramidal neurons and smooth muscle cells. |
| Protein Name | Potassium Voltage-Gated Channel Subfamily B Member 2CdrkVoltage-Gated Potassium Channel Subunit Kv2.2 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinPerikaryonCell ProjectionDendriteLocalized Uniformly Throughout Cell Bodies And DendritesColocalizes With Kcnb1 To High-Density Somatodendritic Clusters On Cortical Pyramidal Neurons |
| Alternative Antibody Names | Anti-Potassium Voltage-Gated Channel Subfamily B Member 2 antibodyAnti-Cdrk antibodyAnti-Voltage-Gated Potassium Channel Subunit Kv2.2 antibodyAnti-Kcnb2 antibody |
Information sourced from Uniprot.org
