Anti-KCNA4 antibody (250-350) (STJ118818)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal KCNA4 (250-350) antibody for use in WB and ELISA in mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | KCNA4 |
| Gene ID | 3739 |
| Uniprot ID | KCNA4_HUMAN |
| Immunogen Region | 250-350 |
| Immunogen Sequence | DIFTEEVKFYQLGEEALLKF REDEGFVREEEDRALPENEF KKQIWLLFEYPESSSPARGI AIVSVLVILISIVIFCLETL PEFRDDRDLVMALSAGGHGG L |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 250-350 of human KCNA4 (NP_002224.1). |
Additional Info
| Tissue Specificity | Expressed in brain, and at lower levels in the testis, lung, kidney, colon and heart. Detected in heart ventricle. |
| Function | Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, and possibly other family members as well.channel properties depend on the type of alpha subunits that are part of the channel. Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Homotetrameric KCNA4 forms a potassium channel that opens in response to membrane depolarization, followed by rapid spontaneous channel closure. Likewise, a heterotetrameric channel formed by KCNA1 and KCNA4 shows rapid inactivation. |
| Protein Name | Potassium Voltage-Gated Channel Subfamily A Member 4Hpcn2Voltage-Gated K(+ Channel HukiiVoltage-Gated Potassium Channel Hbk4Voltage-Gated Potassium Channel Hk1Voltage-Gated Potassium Channel Subunit Kv1.4 |
| Database Links | Reactome: R-HSA-1296072 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinCell ProjectionAxon |
| Alternative Antibody Names | Anti-Potassium Voltage-Gated Channel Subfamily A Member 4 antibodyAnti-Hpcn2 antibodyAnti-Voltage-Gated K(+ Channel Hukii antibodyAnti-Voltage-Gated Potassium Channel Hbk4 antibodyAnti-Voltage-Gated Potassium Channel Hk1 antibodyAnti-Voltage-Gated Potassium Channel Subunit Kv1.4 antibodyAnti-KCNA4 antibodyAnti-KCNA4L antibody |
Information sourced from Uniprot.org