| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Rat/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Protein KASH5 (299-349 aa) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
KASH5 |
| Gene ID: |
147872 |
| Uniprot ID: |
KASH5_HUMAN |
| Immunogen Region: |
299-349 aa |
| Specificity: |
This antibody detects endogenous levels of CC155 at Human |
| Immunogen: |
Synthesized peptide derived from the human CC155 at the amino acid range 299-349 |
| Function | As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Required for telomere attachment to nuclear envelope in the prophase of meiosis. Required for rapid telomere prophase movements implicating a SUN1/2:KASH5 LINC complex in which SUN1 and SUN2 seem to act at least partial redundantly. Required for homolog pairing during meiotic prophase in spermatocytes and probably oocytes. Essential for male and female gametogenesis. Recruits cytoplasmic dynein to telomere attachment sites at the nuclear envelope in spermatocytes. In oocytes is involved in meiotic resumption and spindle formation. |
| Protein Name | Protein Kash5Coiled-Coil Domain-Containing Protein 155Kash Domain-Containing Protein 5 |
| Cellular Localisation | Nucleus Outer MembraneSingle-Pass Type Iv Membrane ProteinCytoplasmic SideNucleusChromosomeTelomereNucleus EnvelopeLocalized Exclusively At Telomeres From The Leptotene To Diplotene StagesColocalizes With Sun2 At Sites Of Telomere Attachment In MeiocytesAt Oocyte Mi Stage Localized Around The SpindleAt Mii Stage Localized To The Spindle Poles |
| Alternative Antibody Names | Anti-Protein Kash5 antibodyAnti-Coiled-Coil Domain-Containing Protein 155 antibodyAnti-Kash Domain-Containing Protein 5 antibodyAnti-KASH5 antibodyAnti-CCDC155 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
