| Host: |
Rabbit |
| Applications: |
IF |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-KANK1 (900-1000) is suitable for use in Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
KANK1 |
| Gene ID: |
23189 |
| Uniprot ID: |
KANK1_HUMAN |
| Immunogen Region: |
900-1000 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 900-1000 of human KANK1 (NP_055973.2). |
| Immunogen Sequence: |
GNYLGYTCKCGGLQSGSPLS SQTSQPEQEVGTSEGKPISS LDAFPTQEGTLSPVNLTDDQ IAAGLYACTNNESTLKSIMK KKDGNKDSNGAKKNLQFVGI N |
| Tissue Specificity | Widely expressed. Isoform 1 is predominantly expressed in heart and kidney. Isoform 2 probably is widely expressed at basic levels. |
| Function | Involved in the control of cytoskeleton formation by regulating actin polymerization. Inhibits actin fiber formation and cell migration. Inhibits RhoA activity.the function involves phosphorylation through PI3K/Akt signaling and may depend on the competitive interaction with 14-3-3 adapter proteins to sequester them from active complexes. Inhibits the formation of lamellipodia but not of filopodia.the function may depend on the competitive interaction with BAIAP2 to block its association with activated RAC1. Inhibits fibronectin-mediated cell spreading.the function is partially mediated by BAIAP2. Inhibits neurite outgrowth. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. In the nucleus, is involved in beta-catenin-dependent activation of transcription. Potential tumor suppressor for renal cell carcinoma. Regulates Rac signaling pathways. |
| Protein Name | Kn Motif And Ankyrin Repeat Domain-Containing Protein 1Ankyrin Repeat Domain-Containing Protein 15Kidney Ankyrin Repeat-Containing Protein |
| Database Links | Reactome: R-HSA-9018519Reactome: R-HSA-9673768 |
| Cellular Localisation | Cell ProjectionRuffle MembraneCytoplasmNucleusColocalizes With Kif21a In Membrane RufflesShuttles Between The Cytoplasm And NucleusIsoform 1: CytoplasmIsoform 2: Cytoplasm |
| Alternative Antibody Names | Anti-Kn Motif And Ankyrin Repeat Domain-Containing Protein 1 antibodyAnti-Ankyrin Repeat Domain-Containing Protein 15 antibodyAnti-Kidney Ankyrin Repeat-Containing Protein antibodyAnti-KANK1 antibodyAnti-ANKRD15 antibodyAnti-KANK antibodyAnti-KIAA0172 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
