Anti-JPH4 antibody (405-605) (STJ112371)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal JPH4 (405-605) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | JPH4 |
| Gene ID | 84502 |
| Uniprot ID | JPH4_HUMAN |
| Immunogen Region | 405-605 |
| Immunogen Sequence | AARMAKLIAQDLQPMLEAPG RRPRQDSEGSDTEPLDEDSP GVYENGLTPSEGSPELPSSP ASSRQPWRPPACRSPLPPGG DQGPFSSPKAWPEEWGGAGA QAEELAGYEAEDEAGMQGPG PRDGSPLLGGCSDSSGSLRE EEGEDEEPLPPLRAPAGTEP EPIAMLVLRGSSSRGPDAGC LTEELGEPAATERPAQPGAA N |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 405-605 of human JPH4 (NP_115828.2). |
Additional Info
| Function | Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH4 is brain-specific and appears to have an active role in certain neurons involved in motor coordination and memory. |
| Protein Name | Junctophilin-4Jp-4Junctophilin-Like 1 Protein |
| Database Links | |
| Cellular Localisation | Cell MembranePeripheral Membrane ProteinEndoplasmic Reticulum MembraneSingle-Pass Type Iv Membrane ProteinLocalized Predominantly On The Plasma MembraneThe Transmembrane Domain Is Anchored In Endoplasmic Reticulum MembraneWhile The N-Terminal Part Associates With The Plasma Membrane |
| Alternative Antibody Names | Anti-Junctophilin-4 antibodyAnti-Jp-4 antibodyAnti-Junctophilin-Like 1 Protein antibodyAnti-JPH4 antibodyAnti-JPHL1 antibodyAnti-KIAA1831 antibody |
Information sourced from Uniprot.org