| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | JPH4 |
| Gene ID: | 84502 |
| Uniprot ID: | JPH4_HUMAN |
| Immunogen Region: | 405-605 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 405-605 of human JPH4 (NP_115828.2). |
| Immunogen Sequence: | AARMAKLIAQDLQPMLEAPG RRPRQDSEGSDTEPLDEDSP GVYENGLTPSEGSPELPSSP ASSRQPWRPPACRSPLPPGG DQGPFSSPKAWPEEWGGAGA QAEELAGYEAEDEAGMQGPG PRDGSPLLGGCSDSSGSLRE EEGEDEEPLPPLRAPAGTEP EPIAMLVLRGSSSRGPDAGC LTEELGEPAATERPAQPGAA N |
| Function | Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH4 is brain-specific and appears to have an active role in certain neurons involved in motor coordination and memory. |
| Protein Name | Junctophilin-4Jp-4Junctophilin-Like 1 Protein |
| Cellular Localisation | Cell MembranePeripheral Membrane ProteinEndoplasmic Reticulum MembraneSingle-Pass Type Iv Membrane ProteinLocalized Predominantly On The Plasma MembraneThe Transmembrane Domain Is Anchored In Endoplasmic Reticulum MembraneWhile The N-Terminal Part Associates With The Plasma Membrane |
| Alternative Antibody Names | Anti-Junctophilin-4 antibodyAnti-Jp-4 antibodyAnti-Junctophilin-Like 1 Protein antibodyAnti-JPH4 antibodyAnti-JPHL1 antibodyAnti-KIAA1831 antibody |
Information sourced from Uniprot.org