Anti-JIP3/Syd2/JSAP1 antibody (N-Term) (STJ70371)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-JIP3/Syd2/JSAP1 (N-Term) is suitable for use in ELISA and Immunohistochemistry research applications. |
| Applications | Pep-ELISA/IHC |
| Host | Goat |
| Reactivity | Human/Mouse/Rat/Cow |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:4000.IHC: In paraffin embedded Mouse Brain shows axonal staining in various regions. Recommended concentration, 4-6µg/ml. |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | MAPK8IP3 |
| Gene ID | 23162 |
| Uniprot ID | JIP3_HUMAN |
| Accession Number | NP_055948.2; NP_001035529.1 |
| Immunogen Region | N-Term |
| Immunogen Sequence | MEIQMDEGGGVV |
| Specificity | This antibody is expected to recognise both reported Human isoforms of this protein (as represented by NP_055948.2 and NP_001035529.1). |
Additional Info
| Function | The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins. Promotes neuronal axon elongation in a kinesin- and JNK-dependent manner. Activates cofilin at axon tips via local activation of JNK, thereby regulating filopodial dynamics and enhancing axon elongation. Its binding to kinesin heavy chains (KHC), promotes kinesin-1 motility along microtubules and is essential for axon elongation and regeneration. Regulates cortical neuronal migration by mediating NTRK2/TRKB anterograde axonal transport during brain development. Acts as an adapter that bridges the interaction between NTRK2/TRKB and KLC1 and drives NTRK2/TRKB axonal but not dendritic anterograde transport, which is essential for subsequent BDNF-triggered signaling and filopodia formation. |
| Protein Name | C-Jun-Amino-Terminal Kinase-Interacting Protein 3Jip-3Jnk-Interacting Protein 3Jnk Map Kinase Scaffold Protein 3Mitogen-Activated Protein Kinase 8-Interacting Protein 3 |
| Cellular Localisation | CytoplasmGolgi ApparatusCytoplasmic VesicleCell ProjectionGrowth ConeAxonDendritePerinuclear RegionLocalized In The Soma And Growth Cones Of Differentiated Neurites And The Golgi And Vesicles Of The Early Secretory Compartment Of Epithelial CellsKif5a/B/C-Mediated Transportation To Axon Tips Is Essential For Its Function In Enhancing Neuronal Axon Elongation |
| Alternative Antibody Names | Anti-C-Jun-Amino-Terminal Kinase-Interacting Protein 3 antibodyAnti-Jip-3 antibodyAnti-Jnk-Interacting Protein 3 antibodyAnti-Jnk Map Kinase Scaffold Protein 3 antibodyAnti-Mitogen-Activated Protein Kinase 8-Interacting Protein 3 antibodyAnti-MAPK8IP3 antibodyAnti-JIP3 antibodyAnti-KIAA1066 antibody |
Information sourced from Uniprot.org