| Host: | Rabbit |
| Applications: | ELISA/IHC/IP/WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-ITPR2 (100-150) is suitable for use in ELISA, Immunohistochemistry, Immunoprecipitation and Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | FITC |
| Isotype: | IgG |
| Formulation: | Contains Tris, HCl/Glycine buffer pH 7.4-7.8, 30% Glycerol and 0.5% BSA, along with cryo-protective agents, Hepes, and long-term preservatives (0.02% Sodium Azide). |
| Purification: | Affinity Purified |
| Concentration: | 0.66 µg/µl |
| Dilution Range: | WB: 1:500 DB: 1:10, 000 ELISA: 1:10, 000 IP: 1:200 IHC: 1:50-1:100 |
| Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: | Itpr2 |
| Gene ID: | 81678 |
| Uniprot ID: | ITPR2_RAT |
| Immunogen Region: | 100-150 |
| Immunogen: | Synthetic peptide taken within amino acid region 100-150 on rat Inosital 1, 4, 5-triphosphate receptor type 2 protein. |
| Post Translational Modifications | Phosphorylation by CaMK2 on Ser-150 significantly decreases the channel open probability. Phosphorylation by cAMP-dependent PKA on Ser-937 increases calcium release. |
| Function | Inositol 1,4,5-trisphosphate-gated calcium channel that upon inositol 1,4,5-trisphosphate binding transports calcium from the endoplasmic reticulum lumen to cytoplasm. Exists in two states.a long-lived closed state where the channel is essentially 'parked' with only very rare visits to an open state and that ligands facilitate the transition from the 'parked' state into a 'drive' mode represented by periods of bursting activity. |
| Protein Name | Inositol 1 -4 -5-Trisphosphate-Gated Calcium Channel Itpr2 Ip3 Receptor Isoform 2 Ip3r 2 Insp3r2 Inositol 1 -4 -5-Trisphosphate Receptor Type 2 Type 2 Inositol 1 -4 -5-Trisphosphate Receptor Type 2 Insp3 Receptor |
| Database Links | Reactome: R-RNO-114508 Reactome: -RNO-139853 Reactome: -RNO-381676 Reactome: -RNO-5578775 Reactome: -RNO-983695 |
| Cellular Localisation | Endoplasmic Reticulum Membrane Multi-Pass Membrane Protein Cytoplasmic Vesicle Secretory Vesicle Membrane Forms Clusters On Endoplasmic Reticulum Membrane Upon Inositol 1 4 5-Trisphosphate Binding |
| Alternative Antibody Names | Anti-Inositol 1 -4 -5-Trisphosphate-Gated Calcium Channel Itpr2 antibody Anti-Ip3 Receptor Isoform 2 antibody Anti-Ip3r 2 antibody Anti-Insp3r2 antibody Anti-Inositol 1 -4 -5-Trisphosphate Receptor Type 2 antibody Anti-Type 2 Inositol 1 -4 -5-Trisphosphate Receptor antibody Anti-Type 2 Insp3 Receptor antibody Anti-Itpr2 antibody |
Information sourced from Uniprot.org