| Post Translational Modifications | Phosphorylation by CaMK2 on Ser-150 significantly decreases the channel open probability. Phosphorylation by cAMP-dependent PKA on Ser-937 increases calcium release. |
| Function | Inositol 1,4,5-trisphosphate-gated calcium channel that upon inositol 1,4,5-trisphosphate binding transports calcium from the endoplasmic reticulum lumen to cytoplasm. Exists in two states.a long-lived closed state where the channel is essentially 'parked' with only very rare visits to an open state and that ligands facilitate the transition from the 'parked' state into a 'drive' mode represented by periods of bursting activity. |
| Protein Name | Inositol 1 -4 -5-Trisphosphate-Gated Calcium Channel Itpr2Ip3 Receptor Isoform 2Ip3r 2Insp3r2Inositol 1 -4 -5-Trisphosphate Receptor Type 2Type 2 Inositol 1 -4 -5-Trisphosphate ReceptorType 2 Insp3 Receptor |
| Database Links | Reactome: R-RNO-114508Reactome: -RNO-139853Reactome: -RNO-381676Reactome: -RNO-5578775Reactome: -RNO-983695 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinCytoplasmic VesicleSecretory Vesicle MembraneForms Clusters On Endoplasmic Reticulum Membrane Upon Inositol 145-Trisphosphate Binding |
| Alternative Antibody Names | Anti-Inositol 1 -4 -5-Trisphosphate-Gated Calcium Channel Itpr2 antibodyAnti-Ip3 Receptor Isoform 2 antibodyAnti-Ip3r 2 antibodyAnti-Insp3r2 antibodyAnti-Inositol 1 -4 -5-Trisphosphate Receptor Type 2 antibodyAnti-Type 2 Inositol 1 -4 -5-Trisphosphate Receptor antibodyAnti-Type 2 Insp3 Receptor antibodyAnti-Itpr2 antibody |
Information sourced from Uniprot.org
