Anti-ITPA antibody (1-194) (STJ114927)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal ITPA (1-194) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ITPA |
| Gene ID | 3704 |
| Uniprot ID | ITPA_HUMAN |
| Immunogen Region | 1-194 |
| Immunogen Sequence | MAASLVGKKIVFVTGNAKKL EEVVQILGDKFPCTLVAQKI DLPEYQGEPDEISIQKCQEA VRQVQGPVLVEDTCLCFNAL GGLPGPYIKWFLEKLKPEGL HQLLAGFEDKSAYALCTFAL STGDPSQPVRLFRGRTSGRI VAPRGCQDFGWDPCFQPDGY EQTYAEMPKAEKNAVSHRFR ALLELQEYFGSLAA |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-194 of human ITPA (NP_258412.1). |
Additional Info
| Tissue Specificity | Ubiquitous. Highly expressed in heart, liver, sex glands, thyroid and adrenal gland. |
| Function | Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. |
| Protein Name | Inosine Triphosphate PyrophosphataseItpaseInosine TriphosphataseNon-Canonical Purine Ntp PyrophosphataseNon-Standard Purine Ntp PyrophosphataseNucleoside-Triphosphate DiphosphataseNucleoside-Triphosphate PyrophosphataseNtpasePutative Oncogene Protein Hlc14-06-PXtp/Ditp Diphosphatase |
| Database Links | Reactome: R-HSA-74259Reactome: R-HSA-9755088 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Inosine Triphosphate Pyrophosphatase antibodyAnti-Itpase antibodyAnti-Inosine Triphosphatase antibodyAnti-Non-Canonical Purine Ntp Pyrophosphatase antibodyAnti-Non-Standard Purine Ntp Pyrophosphatase antibodyAnti-Nucleoside-Triphosphate Diphosphatase antibodyAnti-Nucleoside-Triphosphate Pyrophosphatase antibodyAnti-Ntpase antibodyAnti-Putative Oncogene Protein Hlc14-06-P antibodyAnti-Xtp/Ditp Diphosphatase antibodyAnti-ITPA antibodyAnti-C20orf37 antibodyAnti-My049 antibodyAnti-OK antibodyAnti-SW-cl.9 antibody |
Information sourced from Uniprot.org