| Post Translational Modifications | The ectodomain C-terminal part of the imBRI2 is processed by furin producing a secreted Bri23 peptide and a mature BRI2, membrane form (mBRI2). The remaining part of the ectodomain of mBRI2 containing the BRICHOS domain is cleaved by ADAM10 and is secreted (BRI2C, soluble form). The membrane-bound N-terminal fragment (BRI2C, membrane form) is further proteolytically processed by SPPL2A and SPPL2B through regulated intramembrane proteolysis producing a secreted C-peptide and a BRI2 intracellular domain (BRI2 ICD) released in the cytosol. Shedding by ADAM10 facilitates intramembrane cleavage but is not absolutely required for BRI2 ICD generation. Glycosylation at Asn-170 is important for cell surface localization, but doesn't affect furin- and ADAM10-induced proteolytic processing. |
| Function | Plays a regulatory role in the processing of the amyloid-beta A4 precursor protein (APP) and acts as an inhibitor of the amyloid-beta peptide aggregation and fibrils deposition. Plays a role in the induction of neurite outgrowth. Functions as a protease inhibitor by blocking access of secretases to APP cleavage sites. Mature BRI2 (mBRI2) functions as a modulator of the amyloid-beta A4 precursor protein (APP) processing leading to a strong reduction in the secretion of secretase-processed amyloid-beta protein 40 and amyloid-beta protein 42. Bri23 peptide prevents aggregation of APP amyloid-beta protein 42 into toxic oligomers. |
| Protein Name | Integral Membrane Protein 2bImmature Bri2Imbri2Protein E25bTransmembrane Protein BriBri Cleaved Into - Bri2 - Membrane FormMature Bri2Mbri2 - Bri2 Intracellular DomainBri2 Icd - Bri2c - Soluble Form - Bri23 PeptideBri2-23Abri23C-Terminal PeptideP23 Peptide |
| Database Links | Reactome: R-HSA-977225 |
| Cellular Localisation | Integral Membrane Protein 2b: Golgi Apparatus MembraneSingle-Pass Type Ii Membrane ProteinImmature Bri2 (Imbri2) Is Cleaved By Furin In The Golgi Into Mbri2 And A Bri23 PeptideMbri2 Is Transported To The Plasma Membrane And Bri23 Peptide Is SecretedBri2Membrane Form: Cell MembraneEndosome MembraneMature Bri2 (Mbri2) Needs To Be Transported From The Endoplasmic Reticulum Compartment To The Cell Membrane In Order To Be Able To Inhibit App ProcessingBri23 Peptide: SecretedDetected In The Cerebral Spinal Fluid (Csf)Bri2cSoluble Form: Secreted |
| Alternative Antibody Names | Anti-Integral Membrane Protein 2b antibodyAnti-Immature Bri2 antibodyAnti-Imbri2 antibodyAnti-Protein E25b antibodyAnti-Transmembrane Protein Bri antibodyAnti-Bri Cleaved Into - Bri2 - Membrane Form antibodyAnti-Mature Bri2 antibodyAnti-Mbri2 - Bri2 Intracellular Domain antibodyAnti-Bri2 Icd - Bri2c - Soluble Form - Bri23 Peptide antibodyAnti-Bri2-23 antibodyAnti-Abri23 antibodyAnti-C-Terminal Peptide antibodyAnti-P23 Peptide antibodyAnti-ITM2B antibodyAnti-BRI antibodyAnti-BRI2 antibody |
Information sourced from Uniprot.org
