Anti-ITIH4 antibody (Internal) (STJ71791)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-ITIH4 (Internal) is suitable for use in ELISA and Immunohistochemistry research applications. |
| Applications | Pep-ELISA/IHC |
| Host | Goat |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:16000.WB: Preliminary experiments gave an approx. 150kDa band in Human Liver and Lung lysates after 0.03ยตg/ml antibody staining. Please note that currently we cannot find an explanation in the l |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20ยฐC on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | ITIH4 |
| Gene ID | 3700 |
| Uniprot ID | ITIH4_HUMAN |
| Accession Number | NP_002209.2 |
| Immunogen Region | Internal |
| Immunogen Sequence | ERLCVDPRHRQGPVN |
| Specificity | The immunizing peptide represents a region of the 35kDa chain. This chain is glycosylated giving rise to an apparent higher molecular weight. |
Additional Info
| Post Translational Modifications | Cleaved by plasma kallikrein to yield 100 kDa and 35 kDa fragments, and the resulting 100 kDa fragment is further converted to a 70 kDa fragment. N- and O-glycosylated. In urine, O-linked glycosylation on threonine residues in the region from Thr-719 to Thr-725 consists of core 1 or possibly core 8 glycans. Mainly Hex(HexNAc)(2), but also some Hex(3)(HexNAc)(3). N-glycosylated but not O-glycosylated in plasma. |
| Function | Type II acute-phase protein (APP) involved in inflammatory responses to trauma. May also play a role in liver development or regeneration. |
| Protein Name | Inter-Alpha-Trypsin Inhibitor Heavy Chain H4Iti Heavy Chain H4Iti-Hc4Inter-Alpha-Inhibitor Heavy Chain 4Inter-Alpha-Trypsin Inhibitor Family Heavy Chain-Related ProteinIhrpPlasma Kallikrein Sensitive Glycoprotein 120Gp120Pk-120 Cleaved Into - 70 Kda Inter-Alpha-Trypsin Inhibitor Heavy Chain H4 - 35 Kda Inter-Alpha-Trypsin Inhibitor Heavy Chain H4 |
| Database Links | Reactome: R-HSA-114608 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Inter-Alpha-Trypsin Inhibitor Heavy Chain H4 antibodyAnti-Iti Heavy Chain H4 antibodyAnti-Iti-Hc4 antibodyAnti-Inter-Alpha-Inhibitor Heavy Chain 4 antibodyAnti-Inter-Alpha-Trypsin Inhibitor Family Heavy Chain-Related Protein antibodyAnti-Ihrp antibodyAnti-Plasma Kallikrein Sensitive Glycoprotein 120 antibodyAnti-Gp120 antibodyAnti-Pk-120 Cleaved Into - 70 Kda Inter-Alpha-Trypsin Inhibitor Heavy Chain H4 - 35 Kda Inter-Alpha-Trypsin Inhibitor Heavy Chain H4 antibodyAnti-ITIH4 antibodyAnti-IHRP antibodyAnti-ITIHL1 antibodyAnti-PK120 antibodyAnti-PRO1851 antibody |
Information sourced from Uniprot.org