| Tissue Specificity | Predominantly expressed in lymphoid tissues. |
| Post Translational Modifications | Ubiquitinated. Ubiquitination by TRIM21 in macrophages, a process that is strongly increased upon interferon gamma stimulation, leds to the enhanced transcriptional activity of target cytokine genes. Ubiquitination leads to its degradation by the proteasome. Sumoylated with SUMO3. Desumoylated by SENP1. |
| Function | Transcription factor that specifically binds to the upstream regulatory region of type I interferon (IFN) and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)). Can both act as a transcriptional activator or repressor. Plays a negative regulatory role in cells of the immune system. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of genes. Required for the development of plasmacytoid dendritic cells (pDCs), which produce most of the type I IFN in response to viral infection. Positively regulates macroautophagy in dendritic cells. Acts as a transcriptional repressor of osteoclast differentiation factors such as NFATC1 and EEIG1. |
| Protein Name | Interferon Regulatory Factor 8Irf-8Interferon Consensus Sequence-Binding ProteinH-IcsbpIcsbp |
| Database Links | Reactome: R-HSA-877300Reactome: R-HSA-909733 |
| Cellular Localisation | NucleusCytoplasmIn Resting MacrophagesLocalizes In The CytoplasmTranslocated In The Nucleus Upon Ifn-Gamma Induction |
| Alternative Antibody Names | Anti-Interferon Regulatory Factor 8 antibodyAnti-Irf-8 antibodyAnti-Interferon Consensus Sequence-Binding Protein antibodyAnti-H-Icsbp antibodyAnti-Icsbp antibodyAnti-IRF8 antibodyAnti-ICSBP1 antibody |
Information sourced from Uniprot.org
