| Short Description : | Rabbit polyclonal IRF2BP2 (475-545) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | IRF2BP2 |
| Gene ID: | 359948 |
| Uniprot ID: | I2BP2_HUMAN |
| Immunogen Region: | 475-545 |
| Immunogen Sequence: | GGQGAGNTGGLEPVHPASLP DSSLATSAPLCCTLCHERLE DTHFVQCPSVPSHKFCFPCS RQSIKQQGASG |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 475-545 of human IRF2BP2 (Q7Z5L9). |
| Post Translational Modifications | Phosphorylation at Ser-360 is required for nuclear targeting. |
| Function | Acts as a transcriptional corepressor in a IRF2-dependent manner.this repression is not mediated by histone deacetylase activities. Represses the NFAT1-dependent transactivation of NFAT-responsive promoters. Acts as a coactivator of VEGFA expression in cardiac and skeletal muscles. Plays a role in immature B-cell differentiation. |
| Protein Name | Interferon Regulatory Factor 2-Binding Protein 2Irf-2-Binding Protein 2Irf-2bp2 |
| Database Links | |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Interferon Regulatory Factor 2-Binding Protein 2 antibodyAnti-Irf-2-Binding Protein 2 antibodyAnti-Irf-2bp2 antibodyAnti-IRF2BP2 antibody |
Information sourced from Uniprot.org
