| Tissue Specificity | Expressed in eosinophils, dendritic cells and/or monocytes (at protein level). Expressed predominantly in peripheral blood lymphocytes. |
| Function | Putative inactive protein kinase which regulates signaling downstream of immune receptors including IL1R and Toll-like receptors. Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex. Upon IL33-induced lung inflammation, positively regulates expression of IL6, CSF3, CXCL2 and CCL5 mRNAs in dendritic cells. |
| Protein Name | Interleukin-1 Receptor-Associated Kinase 3Irak-3Il-1 Receptor-Associated Kinase MIrak-MInactive Il-1 Receptor-Associated Kinase 3 |
| Database Links | Reactome: R-HSA-166058Reactome: R-HSA-9020702 |
| Cellular Localisation | CytoplasmNucleusIn Dendritic CellsTranslocates Into The Nucleus Upon Il33 Stimulation |
| Alternative Antibody Names | Anti-Interleukin-1 Receptor-Associated Kinase 3 antibodyAnti-Irak-3 antibodyAnti-Il-1 Receptor-Associated Kinase M antibodyAnti-Irak-M antibodyAnti-Inactive Il-1 Receptor-Associated Kinase 3 antibodyAnti-IRAK3 antibody |
Information sourced from Uniprot.org
