| Short Description : | Rabbit polyclonal IRAK3 (367-596) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IF/ICC/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | IRAK3 |
| Gene ID: | 11213 |
| Uniprot ID: | IRAK3_HUMAN |
| Immunogen Region: | 367-596 |
| Immunogen Sequence: | VLTGCRVVLDDPKHIQLRDL LRELMEKRGLDSCLSFLDKK VPPCPRNFSAKLFCLAGRCA ATRAKLRPSMDEVLNTLEST QASLYFAEDPPTSLKSFRCP SPLFLENVPSIPVEDDESQN NNLLPSDEGLRIDRMTQKTP FECSQSEVMFLSLDKKPESK RNEEACNMPSSSCEESWFPK YIVPSQDLRPYKVNIDPSSE APGHSCRSRPVESSCSSKFS WDEYEQYKKE |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 367-596 of human IRAK3 (NP_009130.2). |
| Tissue Specificity | Expressed in eosinophils, dendritic cells and/or monocytes (at protein level). Expressed predominantly in peripheral blood lymphocytes. |
| Function | Putative inactive protein kinase which regulates signaling downstream of immune receptors including IL1R and Toll-like receptors. Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex. Upon IL33-induced lung inflammation, positively regulates expression of IL6, CSF3, CXCL2 and CCL5 mRNAs in dendritic cells. |
| Protein Name | Interleukin-1 Receptor-Associated Kinase 3Irak-3Il-1 Receptor-Associated Kinase MIrak-MInactive Il-1 Receptor-Associated Kinase 3 |
| Database Links | Reactome: R-HSA-166058Reactome: R-HSA-9020702 |
| Cellular Localisation | CytoplasmNucleusIn Dendritic CellsTranslocates Into The Nucleus Upon Il33 Stimulation |
| Alternative Antibody Names | Anti-Interleukin-1 Receptor-Associated Kinase 3 antibodyAnti-Irak-3 antibodyAnti-Il-1 Receptor-Associated Kinase M antibodyAnti-Irak-M antibodyAnti-Inactive Il-1 Receptor-Associated Kinase 3 antibodyAnti-IRAK3 antibody |
Information sourced from Uniprot.org
