Anti-IPO9 antibody (827-1041) (STJ114124)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal IPO9 (827-1041) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | IPO9 |
| Gene ID | 55705 |
| Uniprot ID | IPO9_HUMAN |
| Immunogen Region | 827-1041 |
| Immunogen Sequence | LPGPTGKPALEFVMAEWTSR QHLFYGQYEGKVSSVALCKL LQHGINADDKRLQDIRVKGE EIYSMDEGIRTRSKSAKNPE RWTNIPLLVKILKLIINELS NVMEANAARQATPAEWSQDD SNDMWEDQEEEEEEEEDGLA GQLLSDILATSKYEEDYYED DEEDDPDALKDPLYQIDLQA YLTDFLCQFAQQPCYIMFSG HLNDNERRVLQTIGI |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 827-1041 of human IPO9 (NP_060555.2). |
Additional Info
| Function | Nuclear transport receptor that mediates nuclear import of proteins, such as histones, proteasome and actin. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates the import of pre-assembled proteasomes into the nucleus.AKIRIN2 acts as a molecular bridge between IPO9 and the proteasome complex. Mediates the nuclear import of histones H2A, H2B, H4 and H4. In addition to nuclear import, also acts as a chaperone for histones by preventing inappropriate non-nucleosomal interactions. Mediates the nuclear import of actin. |
| Protein Name | Importin-9Imp9Ran-Binding Protein 9Ranbp9 |
| Database Links | |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Importin-9 antibodyAnti-Imp9 antibodyAnti-Ran-Binding Protein 9 antibodyAnti-Ranbp9 antibodyAnti-IPO9 antibodyAnti-IMP9 antibodyAnti-KIAA1192 antibodyAnti-RANBP9 antibodyAnti-HSPC273 antibody |
Information sourced from Uniprot.org