Anti-INTS7 antibody (702-948) (STJ118553)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal INTS7 (702-948) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | INTS7 |
| Gene ID | 25896 |
| Uniprot ID | INT7_HUMAN |
| Immunogen Region | 702-948 |
| Immunogen Sequence | NVELQQQSCLLISHAIEALI LDPESASFQEYGSTGTAHAD SEYERRMMSVYNHVLEEHTA CLCNAIIALLKVPLSFQRYF FQKLQSTSIKLALSPSPRNP AEPIAVQNNQQLALKVEGVV QHGSKPGLFRKIQSVCLNVS STLQSKSGQDYKIPIDNMTN EMEQRVEPHNDYFSTQFLLN FAILGTHNITVESSVKDANG IVWKTGPRTTIFVKSLEDPY SQQIRLQQQQAQQPLQQQQ |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 702-948 of human INTS7 (NP_001186740.1). |
Additional Info
| Function | Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes. The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA. The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs). May be not involved in the recruitment of cytoplasmic dynein to the nuclear envelope by different components of the INT complex. Plays a role in DNA damage response (DDR) signaling during the S phase. |
| Protein Name | Integrator Complex Subunit 7Int7 |
| Database Links | Reactome: R-HSA-6807505 |
| Cellular Localisation | NucleusChromosomeCytoplasmLocalizes To Sites Of Dna Damage In A H2ax-Independent Manner |
| Alternative Antibody Names | Anti-Integrator Complex Subunit 7 antibodyAnti-Int7 antibodyAnti-INTS7 antibodyAnti-C1orf73 antibody |
Information sourced from Uniprot.org