| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | INTS7 |
| Gene ID: | 25896 |
| Uniprot ID: | INT7_HUMAN |
| Immunogen Region: | 702-948 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 702-948 of human INTS7 (NP_001186740.1). |
| Immunogen Sequence: | NVELQQQSCLLISHAIEALI LDPESASFQEYGSTGTAHAD SEYERRMMSVYNHVLEEHTA CLCNAIIALLKVPLSFQRYF FQKLQSTSIKLALSPSPRNP AEPIAVQNNQQLALKVEGVV QHGSKPGLFRKIQSVCLNVS STLQSKSGQDYKIPIDNMTN EMEQRVEPHNDYFSTQFLLN FAILGTHNITVESSVKDANG IVWKTGPRTTIFVKSLEDPY SQQIRLQQQQAQQPLQQQQ |
| Function | Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Plays a role in DNA damage response (DDR) signaling during the S phase. May be not involved in the recruitment of cytoplasmic dynein to the nuclear envelope by different components of the INT complex. |
| Protein Name | Integrator Complex Subunit 7Int7 |
| Database Links | Reactome: R-HSA-6807505 |
| Cellular Localisation | NucleusChromosomeCytoplasmLocalizes To Sites Of Dna Damage In A H2ax-Independent Manner |
| Alternative Antibody Names | Anti-Integrator Complex Subunit 7 antibodyAnti-Int7 antibodyAnti-INTS7 antibodyAnti-C1orf73 antibody |
Information sourced from Uniprot.org