| Function | Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes. The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA. The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs). May be not involved in the recruitment of cytoplasmic dynein to the nuclear envelope by different components of the INT complex. Plays a role in DNA damage response (DDR) signaling during the S phase. |
| Protein Name | Integrator Complex Subunit 7Int7 |
| Database Links | Reactome: R-HSA-6807505 |
| Cellular Localisation | NucleusChromosomeCytoplasmLocalizes To Sites Of Dna Damage In A H2ax-Independent Manner |
| Alternative Antibody Names | Anti-Integrator Complex Subunit 7 antibodyAnti-Int7 antibodyAnti-INTS7 antibodyAnti-C1orf73 antibody |
Information sourced from Uniprot.org
