• Western blot analysis of various lysates using INTS7 Rabbit polyclonal antibody (STJ118553) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 5s.

Anti-INTS7 antibody (702-948) (STJ118553)

SKU:
STJ118553

£112.50 - £522.50
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Host: Rabbit
Applications: WB
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-INTS7 (702-948) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: INTS7
Gene ID: 25896
Uniprot ID: INT7_HUMAN
Immunogen Region: 702-948
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 702-948 of human INTS7 (NP_001186740.1).
Immunogen Sequence: NVELQQQSCLLISHAIEALI LDPESASFQEYGSTGTAHAD SEYERRMMSVYNHVLEEHTA CLCNAIIALLKVPLSFQRYF FQKLQSTSIKLALSPSPRNP AEPIAVQNNQQLALKVEGVV QHGSKPGLFRKIQSVCLNVS STLQSKSGQDYKIPIDNMTN EMEQRVEPHNDYFSTQFLLN FAILGTHNITVESSVKDANG IVWKTGPRTTIFVKSLEDPY SQQIRLQQQQAQQPLQQQQ
Function Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Plays a role in DNA damage response (DDR) signaling during the S phase. May be not involved in the recruitment of cytoplasmic dynein to the nuclear envelope by different components of the INT complex.
Protein Name Integrator Complex Subunit 7
Int7
Database Links Reactome: R-HSA-6807505
Cellular Localisation Nucleus
Chromosome
Cytoplasm
Localizes To Sites Of Dna Damage In A H2ax-Independent Manner
Alternative Antibody Names Anti-Integrator Complex Subunit 7 antibody
Anti-Int7 antibody
Anti-INTS7 antibody
Anti-C1orf73 antibody

Information sourced from Uniprot.org

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