Anti-Interferon-Gamma antibody (STJ16101146)

SKU:
STJ16101146-1

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Host: Rabbit
Applications: IHC-F/ELISA/WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Interferon-Gamma is suitable for use in Immunohistochemistry, ELISA and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: Ig
Formulation: PBS with 0.1% BSA and 0.02% sodium azide
Purification: Affinity purified
Concentration: 100 ug/mL
Storage Instruction: Store at 2-8°C upon receipt.
Gene Symbol: IFNG
Gene ID: 3458
Uniprot ID: IFNG_HUMAN
Tissue Specificity Released primarily from activated T lymphocytes.
Post Translational Modifications Proteolytic processing produces C-terminal heterogeneity, with proteins ending alternatively at Gly-150, Met-157 or Gly-161.
Function Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation. Primarily signals through the JAK-STAT pathway after interaction with its receptor IFNGR1 to affect gene regulation. Upon IFNG binding, IFNGR1 intracellular domain opens out to allow association of downstream signaling components JAK2, JAK1 and STAT1, leading to STAT1 activation, nuclear translocation and transcription of IFNG-regulated genes. Many of the induced genes are transcription factors such as IRF1 that are able to further drive regulation of a next wave of transcription. Plays a role in class I antigen presentation pathway by inducing a replacement of catalytic proteasome subunits with immunoproteasome subunits. In turn, increases the quantity, quality, and repertoire of peptides for class I MHC loading. Increases the efficiency of peptide generation also by inducing the expression of activator PA28 that associates with the proteasome and alters its proteolytic cleavage preference. Up-regulates as well MHC II complexes on the cell surface by promoting expression of several key molecules such as cathepsins B/CTSB, H/CTSH, and L/CTSL. Participates in the regulation of hematopoietic stem cells during development and under homeostatic conditions by affecting their development, quiescence, and differentiation.
Protein Name Interferon Gamma
Ifn-Gamma
Immune Interferon
Database Links Reactome: R-HSA-877300
Reactome: R-HSA-877312
Reactome: R-HSA-8877330
Reactome: R-HSA-8950505
Reactome: R-HSA-9732724
Cellular Localisation Secreted
Alternative Antibody Names Anti-Interferon Gamma antibody
Anti-Ifn-Gamma antibody
Anti-Immune Interferon antibody
Anti-IFNG antibody

Information sourced from Uniprot.org

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