| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: | ITGA2 |
| Gene ID: | 3673 |
| Uniprot ID: | ITA2_HUMAN |
| Immunogen Region: | 1-100 aa |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Integrin alpha 2 (ITGA2/CD49b) (NP_002194.2). |
| Immunogen Sequence: | MGPERTGAAPLPLLLVLALS QGILNCCLAYNVGLPEAKIF SGPSSEQFGYAVQQFINPKG NWLLVGSPWSGFPENRMGDV YKCPVDLSTATCEKLNLQTS |
| Function | Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix. (Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human rotavirus A. (Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human echoviruses 1 and 8. |
| Protein Name | Integrin Alpha-2Cd49 Antigen-Like Family Member BCollagen ReceptorPlatelet Membrane Glycoprotein IaGpiaVla-2 Subunit AlphaCd Antigen Cd49b |
| Database Links | Reactome: R-HSA-216083Reactome: R-HSA-3000157Reactome: R-HSA-3000170Reactome: R-HSA-3000178Reactome: R-HSA-447041Reactome: R-HSA-75892Reactome: R-HSA-8874081 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Integrin Alpha-2 antibodyAnti-Cd49 Antigen-Like Family Member B antibodyAnti-Collagen Receptor antibodyAnti-Platelet Membrane Glycoprotein Ia antibodyAnti-Gpia antibodyAnti-Vla-2 Subunit Alpha antibodyAnti-Cd Antigen Cd49b antibodyAnti-ITGA2 antibodyAnti-CD49B antibody |
Information sourced from Uniprot.org