Anti-ING2 antibody (STJ191949)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from part of the human protein
General Information
| Short Description | Rabbit polyclonal anti-Inhibitor of growth protein 2 for use in WB and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ING2 |
| Gene ID | 3622 |
| Uniprot ID | ING2_HUMAN |
| Immunogen | Synthesized peptide derived from part of the human protein |
| Specificity | ING2 Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Post Translational Modifications | Sumoylation enhances its association with SIN3A and is required for binding to some target gene promoters, this is the case for TMEM71. |
| Function | Seems to be involved in p53/TP53 activation and p53/TP53-dependent apoptotic pathways, probably by enhancing acetylation of p53/TP53. Component of a mSin3A-like corepressor complex, which is probably involved in deacetylation of nucleosomal histones. ING2 activity seems to be modulated by binding to phosphoinositides (PtdInsPs). |
| Protein Name | Inhibitor Of Growth Protein 2Inhibitor Of Growth 1-Like ProteinIng1lpP32P33ing2 |
| Database Links | Reactome: R-HSA-3899300Reactome: R-HSA-6811555 |
| Cellular Localisation | NucleusPredominantly NuclearLocalized To Chromatin And Nuclear MatrixUpon Reduced Ptdins(5)P Levels Seems To Be Released From Chromatin AndAt Least PartiallyTranslocated To The Cytoplasm |
| Alternative Antibody Names | Anti-Inhibitor Of Growth Protein 2 antibodyAnti-Inhibitor Of Growth 1-Like Protein antibodyAnti-Ing1lp antibodyAnti-P32 antibodyAnti-P33ing2 antibodyAnti-ING2 antibodyAnti-ING1L antibody |
Information sourced from Uniprot.org