| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Inhibitor of growth protein 2 is suitable for use in Western Blot and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 ELISA 1:5000-20000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ING2 |
| Gene ID: | 3622 |
| Uniprot ID: | ING2_HUMAN |
| Specificity: | ING2 Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: | Synthesized peptide derived from part of the human protein |
| Post Translational Modifications | Sumoylation enhances its association with SIN3A and is required for binding to some target gene promoters, this is the case for TMEM71. |
| Function | Seems to be involved in p53/TP53 activation and p53/TP53-dependent apoptotic pathways, probably by enhancing acetylation of p53/TP53. Component of a mSin3A-like corepressor complex, which is probably involved in deacetylation of nucleosomal histones. ING2 activity seems to be modulated by binding to phosphoinositides (PtdInsPs). |
| Protein Name | Inhibitor Of Growth Protein 2 Inhibitor Of Growth 1-Like Protein Ing1lp P32 P33ing2 |
| Database Links | Reactome: R-HSA-3899300 Reactome: R-HSA-6811555 |
| Cellular Localisation | Nucleus Predominantly Nuclear Localized To Chromatin And Nuclear Matrix Upon Reduced Ptdins(5)P Levels Seems To Be Released From Chromatin And At Least Partially Translocated To The Cytoplasm |
| Alternative Antibody Names | Anti-Inhibitor Of Growth Protein 2 antibody Anti-Inhibitor Of Growth 1-Like Protein antibody Anti-Ing1lp antibody Anti-P32 antibody Anti-P33ing2 antibody Anti-ING2 antibody Anti-ING1L antibody |
Information sourced from Uniprot.org