| Short Description : | Rabbit polyclonal ING1 (80-180 aa) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ING1 |
| Gene ID: | 3621 |
| Uniprot ID: | ING1_HUMAN |
| Immunogen Region: | 80-180 aa |
| Immunogen Sequence: | LRCGWFSSWPPPSKSAIPIG GGSRGAGRVSRWPPPHWLEA WRVSPLPLSPLSPATFGRGF IAVAVIPGLWARGRGCSSDR LPRPAGPARRQFQAASLLTR GWGRAWPWKQILKELDECYE RFSRETDGAQKRRMLHCVQR ALIRSQELGDEKIQIVSQMV ELVENRTRQVDSHVELFEAQ |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 80-180 of human ING1 (NP_937862.1). |
| Tissue Specificity | Isoform 2 was expressed in all normal tissues and cells examined, as well as in all breast cancer and melanoma cell lines examined. Isoform 3 was expressed in testis, liver, and kidney, weakly expressed in colon and brain and not expressed in breast and cultured melanocytes. Isoform 4 was highly expressed in testis and weakly expressed in brain, but not expressed in breast, colon, kidney, melanocytes, breast cancer or melanoma cell lines. |
| Function | Cooperates with p53/TP53 in the negative regulatory pathway of cell growth by modulating p53-dependent transcriptional activation. Implicated as a tumor suppressor gene. |
| Protein Name | Inhibitor Of Growth Protein 1 |
| Database Links | |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Inhibitor Of Growth Protein 1 antibodyAnti-ING1 antibody |
Information sourced from Uniprot.org
