| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Protein INCA1 (10-60 aa) is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | INCA1 |
| Gene ID: | 388324 |
| Uniprot ID: | INCA1_HUMAN |
| Immunogen Region: | 10-60 aa |
| Specificity: | This antibody detects endogenous levels of INCA1 at Human/Mouse |
| Immunogen: | Synthesized peptide derived from the human INCA1 at the amino acid range 10-60 |
| Post Translational Modifications | Phosphorylated when part of a complex with CCNA1 and CDK2. Strongly phosphorylated by CDK2 on its C-terminal region spanning amino acid 149-221. Less intensively phosphorylated by CDK2 on its first 75 amino acid residues. |
| Function | Binds to CDK2-bound cyclins and inhibits the kinase activity of CDK2.binding to cyclins is critical for its function as CDK inhibitor. Inhibits cell growth and cell proliferation and may play a role in cell cycle control. Required for ING5-mediated regulation of S-phase progression, enhancement of Fas-induced apoptosis and inhibition of cell growth. |
| Protein Name | Protein Inca1Inhibitor Of Cdk Interacting With Cyclin A1 |
| Cellular Localisation | NucleusCytoplasm |
| Alternative Antibody Names | Anti-Protein Inca1 antibodyAnti-Inhibitor Of Cdk Interacting With Cyclin A1 antibodyAnti-INCA1 antibodyAnti-HSD45 antibody |
Information sourced from Uniprot.org