| Host: | Goat |
| Applications: | Pep-ELISA/WB |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Goat polyclonal antibody anti-INCA/CARD17 (C-Term) is suitable for use in ELISA and Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:8000.WB: Approx 15kDa double band observed in Human Kidney and Lung lysates (calculated MW of 11.9kDa according to NP_001007233.1). Recommended concentration: 0.5-1.5µg/ml. |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Immunogen Region: | C-Term |
| Accession Number: | NP_001007233.1 |
| Immunogen Sequence: | NHLTTQDSQIVLPS |
| Function | Regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-IL-1beta/IL1B and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. However, unlike CASP1, do not induce NF-kappa-B activation. |
| Protein Name | Caspase Recruitment Domain-Containing Protein 17Caspase-1 Inhibitor IncaInhibitory Caspase Recruitment Domain Protein |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Caspase Recruitment Domain-Containing Protein 17 antibodyAnti-Caspase-1 Inhibitor Inca antibodyAnti-Inhibitory Caspase Recruitment Domain Protein antibodyAnti-CARD17 antibodyAnti-INCA antibody |
Information sourced from Uniprot.org
