| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Inosine-5 monophosphate dehydrogenase 2 is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | IMPDH2 |
| Gene ID: | 3615 |
| Uniprot ID: | IMDH2_HUMAN |
| Specificity: | This antibody detects endogenous levels of IMPDH2 at Human, Mouse, Rat |
| Immunogen: | Synthesized peptide derived from human IMPDH2 |
| Post Translational Modifications | Ubiquitinated leading to its degradation by the proteasome. The N-terminus is blocked. Acetylated by CLOCK in a circadian manner. |
| Function | Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. |
| Protein Name | Inosine-5'-Monophosphate Dehydrogenase 2 Imp Dehydrogenase 2 Impd 2 Impdh 2 Inosine-5'-Monophosphate Dehydrogenase Type Ii Imp Dehydrogenase Ii Impdh-Ii |
| Database Links | Reactome: R-HSA-6798695 Reactome: R-HSA-73817 Reactome: R-HSA-9679191 Reactome: R-HSA-9748787 |
| Cellular Localisation | Cytoplasm Nucleus Cytosol Can Form Fiber-Like Subcellular Structures Termed 'Cytoophidia' In Response To Intracellular Guanine-Nucleotide Depletion |
| Alternative Antibody Names | Anti-Inosine-5'-Monophosphate Dehydrogenase 2 antibody Anti-Imp Dehydrogenase 2 antibody Anti-Impd 2 antibody Anti-Impdh 2 antibody Anti-Inosine-5'-Monophosphate Dehydrogenase Type Ii antibody Anti-Imp Dehydrogenase Ii antibody Anti-Impdh-Ii antibody Anti-IMPDH2 antibody Anti-IMPD2 antibody |
Information sourced from Uniprot.org