Anti-IMPACT antibody (123-173 aa) (STJ194083)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human IMPCT at the amino acid range 123-173
General Information
| Short Description | Rabbit polyclonal anti-Protein IMPACT (123-173 aa) for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | IMPACT |
| Gene ID | 55364 |
| Uniprot ID | IMPCT_HUMAN |
| Immunogen | Synthesized peptide derived from the human IMPCT at the amino acid range 123-173 |
| Immunogen Region | 123-173 aa |
| Specificity | This antibody detects endogenous levels of IMPCT at Human/Mouse/Rat |
Additional Info
| Function | Translational regulator that ensures constant high levels of translation upon a variety of stress conditions, such as amino acid starvation, UV-C irradiation, proteasome inhibitor treatment and glucose deprivation. Plays a role as a negative regulator of the EIF2AK4/GCN2 kinase activity.impairs GCN1-mediated EIF2AK4/GCN2 activation, and hence EIF2AK4/GCN2-mediated eIF-2-alpha phosphorylation and subsequent down-regulation of protein synthesis. May be required to regulate translation in specific neuronal cells under amino acid starvation conditions by preventing GCN2 activation and therefore ATF4 synthesis. Through its inhibitory action on EIF2AK4/GCN2, plays a role in differentiation of neuronal cells by stimulating neurite outgrowth. |
| Protein Name | Protein ImpactImprinted And Ancient Gene Protein Homolog |
| Database Links | Reactome: R-HSA-9633012 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Protein Impact antibodyAnti-Imprinted And Ancient Gene Protein Homolog antibodyAnti-IMPACT antibody |
Information sourced from Uniprot.org