| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | IL7 |
| Gene ID: | 3574 |
| Uniprot ID: | IL7_HUMAN |
| Immunogen Region: | 26-177 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 26-177 of human IL7 (NP_000871.1). |
| Immunogen Sequence: | DCDIEGKDGKQYESVLMVSI DQLLDSMKEIGSNCLNNEFN FFKRHICDANKEGMFLFRAA RKLRQFLKMNSTGDFDLHLL KVSEGTTILLNCTGQVKGRK PAALGEAQPTKSLEENKSLK EQKKLNDLCFLKRLLQEIKT CWNKILMGTKEH |
| Function | Hematopoietic cytokine that plays an essential role in the development, expansion, and survival of naive and memory T-cells and B-cells thereby regulating the number of mature lymphocytes and maintaining lymphoid homeostasis. Mechanistically, exerts its biological effects through a receptor composed of IL7RA subunit and the cytokine receptor common subunit gamma/CSF2RG. Binding to the receptor leads to activation of various kinases including JAK1 or JAK3 depending on the cell type and subsequently propagation of signals through activation of several downstream signaling pathways including the PI3K/Akt/mTOR or the JAK-STAT5. |
| Protein Name | Interleukin-7Il-7 |
| Database Links | Reactome: R-HSA-1266695 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Interleukin-7 antibodyAnti-Il-7 antibodyAnti-IL7 antibody |
Information sourced from Uniprot.org