| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Rat/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-L-amino-acid oxidase (N-Term) is suitable for use in Western Blot and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-1:2000ELISA 1:40000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
IL4I1 |
| Gene ID: |
259307 |
| Uniprot ID: |
OXLA_HUMAN |
| Immunogen Region: |
N-Term |
| Specificity: |
IL-4I1 Polyclonal Antibody detects endogenous levels of IL-4I1 protein. |
| Immunogen: |
Synthesized peptide derived from the N-terminal region of human IL-4I1. |
| Post Translational Modifications | N-glycosylated. |
| Function | Secreted L-amino-acid oxidase that acts as a key immunoregulator. Has preference for L-aromatic amino acids: converts phenylalanine (Phe), tyrosine (Tyr) and tryptophan (Trp) to phenylpyruvic acid (PP), hydroxyphenylpyruvic acid (HPP), and indole-3-pyruvic acid (I3P), respectively. Also has weak L-arginine oxidase activity. Acts as a negative regulator of anti-tumor immunity by mediating Trp degradation via an indole pyruvate pathway that activates the transcription factor AHR. IL4I1-mediated Trp catabolism generates I3P, giving rise to indole metabolites (indole-3-acetic acid (IAA) and indole-3-aldehyde (I3A)) and kynurenic acid, which act as ligands for AHR, a ligand-activated transcription factor that plays important roles in immunity and cancer. AHR activation by indoles following IL4I1-mediated Trp degradation enhances tumor progression by promoting cancer cell motility and suppressing adaptive immunity. Also has an immunoregulatory function in some immune cells, probably by mediating Trp degradation and promoting downstream AHR activation: inhibits T-cell activation and proliferation, promotes the differentiation of naive CD4(+) T-cells into FOXP3(+) regulatory T-cells (Treg) and regulates the development and function of B-cells. Also regulates M2 macrophage polarization by inhibiting T-cell activation. Also has antibacterial properties by inhibiting growth of Gram negative and Gram positive bacteria through the production of NH4(+) and H2O2. |
| Protein Name | L-Amino-Acid OxidaseLaaoLaoInterleukin-4-Induced Protein 1Il4-Induced Protein 1Hil4i1Protein Fig-1Hfig1 |
| Database Links | Reactome: R-HSA-8964208 |
| Cellular Localisation | SecretedLysosomeCytoplasmic VesicleSecretory VesicleAcrosomeSecreted At The Immunological Synapse |
| Alternative Antibody Names | Anti-L-Amino-Acid Oxidase antibodyAnti-Laao antibodyAnti-Lao antibodyAnti-Interleukin-4-Induced Protein 1 antibodyAnti-Il4-Induced Protein 1 antibodyAnti-Hil4i1 antibodyAnti-Protein Fig-1 antibodyAnti-Hfig1 antibodyAnti-IL4I1 antibodyAnti-FIG1 antibodyAnti-UNQ636 antibodyAnti-PRO1265 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
