Anti-IL24 antibody (131-180 aa) (STJ96776)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human IL24 at the amino acid range 131-180
General Information
| Short Description | Rabbit polyclonal anti-Interleukin-24 (131-180 aa) for use in WB, IHC, IF and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC-P 1:100-1:300ELISA 1:20000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | IL24 |
| Gene ID | 11009 |
| Uniprot ID | IL24_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the Internal region of human IL24 at the amino acid range 131-180 |
| Immunogen Region | 131-180 aa |
| Specificity | MDA-7 Polyclonal Antibody detects endogenous levels of MDA-7 protein. |
Additional Info
| Post Translational Modifications | Glycosylated. Ubiquitination at Lys-122 promotes proteasomal degradation. |
| Function | Multifunctional cytokine mainly produced by T-cells that plays a regulatory role in immune response, tissue homeostasis, host defense, and oncogenesis. Possesses antiviral functions and induces the type I interferon response during influenza infection. Signals through two receptor complexes IL20RA/IL20RB or IL20RB/IL22RA1. In turn, stimulates the JAK1-STAT3 and MAPK pathways and promotes the secretion of pro-inflammatory mediators including IL8 and MMP1. Intracellularly, maintains endoplasmic reticulum homeostasis by restricting the eIF2alpha-CHOP pathway-mediated stress signal. In addition, acts as a quality control mechanism for the ubiquitin proteasome system by alerting the cell to proteasome dysfunction through activation of PKR/EIF2AK2. |
| Protein Name | Interleukin-24Il-24Melanoma Differentiation-Associated Gene 7 ProteinMda-7Suppression Of Tumorigenicity 16 Protein |
| Database Links | Reactome: R-HSA-8854691 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Interleukin-24 antibodyAnti-Il-24 antibodyAnti-Melanoma Differentiation-Associated Gene 7 Protein antibodyAnti-Mda-7 antibodyAnti-Suppression Of Tumorigenicity 16 Protein antibodyAnti-IL24 antibodyAnti-MDA7 antibodyAnti-ST16 antibody |
Information sourced from Uniprot.org