• Immunofluorescence analysis of L929 cells using IL23R Rabbit polyclonal antibody (STJ24181) at dilution of 1:100. Blue: DAPI for nuclear staining.
  • Immunohistochemistry analysis of paraffin-embedded Human thyroid cancer using IL23R Rabbit polyclonal antibody (STJ24181) at dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7. 2 before commencing with immunohistochemistry staining protocol.
  • Immunohistochemistry analysis of paraffin-embedded Rat kidney using IL23R Rabbit polyclonal antibody (STJ24181) at dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7. 2 before commencing with immunohistochemistry staining protocol.
  • Immunohistochemistry analysis of paraffin-embedded Mouse kidney using IL23R Rabbit polyclonal antibody (STJ24181) at dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7. 2 before commencing with immunohistochemistry staining protocol.
  • Western blot analysis of K-562, using IL23R Rabbit polyclonal antibody (STJ24181) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s.

Anti-IL23R antibody (510-629) (STJ24181)

SKU:
STJ24181

£112.50 - £522.50
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Host: Rabbit
Applications: WB/IHC/IF
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-IL23R (510-629) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.05% Proclin300, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:1000
IHC-P 1:50-1:200
IF/ICC 1:50-1:100
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: IL23R
Gene ID: 149233
Uniprot ID: IL23R_HUMAN
Immunogen Region: 510-629
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 510-629 of human IL23R (NP_653302.2).
Immunogen Sequence: KPPVDSLDSGNNPRLQKHPN FAFSVSSVNSLSNTIFLGEL SLILNQGECSSPDIQNSVEE ETTMLLENDSPSETIPEQTL LPDEFVSCLGIVNEELPSIN TYFPQNILESHFNRISLLEK
Tissue Specificity Expressed by monocytes, Th1, Th0, NK and dendritic cells. Isoform 1 is specifically expressed in NK cells.
Post Translational Modifications Phosphorylated in response to IL23.
Function Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis.
Protein Name Interleukin-23 Receptor
Il-23 Receptor
Il-23r
Database Links Reactome: R-HSA-6785807
Reactome: R-HSA-9020933
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Antibody Names Anti-Interleukin-23 Receptor antibody
Anti-Il-23 Receptor antibody
Anti-Il-23r antibody
Anti-IL23R antibody

Information sourced from Uniprot.org

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