Anti-IL23A antibody (75-105) {FITC} (STJ501443)

SKU:
STJ501443-100

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Host: Rabbit
Applications: ELISA/WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-IL23A (75-105) is suitable for use in ELISA and Western Blot research applications.
Clonality: Polyclonal
Conjugation: FITC
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.74-0.90 µg/µl
Dilution Range: WB: 1:250
DB: 1:10, 000
ELISA: 1:10, 000
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: IL23A
Gene ID: 51561
Uniprot ID: IL23A_HUMAN
Immunogen Region: 75-105
Specificity: Does not cross react with other Interleukins or other proteins.
Immunogen: Synthetic peptide taken within amino acid region 75-105 on IL23P19 protein.
Tissue Specificity Secreted by activated dendritic and phagocytic cells and keratinocytes. Also expressed by dermal Langerhans cells (at protein level).
Function Associates with IL12B to form the pro-inflammatory cytokine IL-23 that plays different roles in innate and adaptive immunity. Released by antigen-presenting cells such as dendritic cells or macrophages, binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R to activate JAK2 and TYK2 which then phosphorylate the receptor to form a docking site leading to the phosphorylation of STAT3 and STAT4. This process leads to activation of several pathways including p38 MAPK or NF-kappa-B and promotes the production of pro-inflammatory cytokines such as interleukin-17A/IL17A. In turn, participates in the early and effective intracellular bacterial clearance. Promotes the expansion and survival of T-helper 17 cells, a CD4-positive helper T-cell subset that produces IL-17, as well as other IL-17-producing cells.
Protein Name Interleukin-23 Subunit Alpha
Il-23 Subunit Alpha
Il-23-A
Interleukin-23 Subunit P19
Il-23p19
Database Links Reactome: R-HSA-6785807
Reactome: R-HSA-9020933
Cellular Localisation Secreted
Secreted Upon Association With Il12b
Alternative Antibody Names Anti-Interleukin-23 Subunit Alpha antibody
Anti-Il-23 Subunit Alpha antibody
Anti-Il-23-A antibody
Anti-Interleukin-23 Subunit P19 antibody
Anti-Il-23p19 antibody
Anti-IL23A antibody
Anti-SGRF antibody
Anti-UNQ2498 antibody
Anti-PRO5798 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance