Anti-Il2 antibody [JES6-5H4] (STJA0002142)

SKU:
STJA0002142

£148.50 - £513.50
Current Stock:
Host: Rat
Applications: Neut/Stim/ICFC/IHC/IP
Reactivity: Mouse
Note: FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS.
Short Description: Rat monoclonal antibody anti-Interleukin-2 is suitable for use in Universal, Universal, IConfocal MicroscopyC, Immunohistochemistry and Immunoprecipitation research applications.
Clonality: Monoclonal
Clone ID: JES6-5H4
Conjugation: Unconjugated
Isotype: IgG2bk
Formulation: 0.2 µm filtered in PBS, pH7.2. Azide Free (AF) /Low Endotoxin (LE) : Contains no stabilizers or preservatives. Endotoxin level is < 2 EU/mg as determined by LAL gel clotting assay.
Concentration: 0.5 mg/mL
Storage Instruction: Store at 2-8°C. Do not freeze this product.
Gene Symbol: Il2
Gene ID: 16183
Uniprot ID: IL2_MOUSE
Tissue Specificity Produced by immune cells including dendritic cells. In contrast, macrophages do not produce IL2 upon bacterial stimulation.
Function Cytokine produced by activated CD4-positive helper T-cells and to a lesser extend activated CD8-positive T-cells and natural killer (NK) cells that plays pivotal roles in the immune response and tolerance. Binds to a receptor complex composed of either the high-affinity trimeric IL-2R (IL2RA/CD25, IL2RB/CD122 and IL2RG/CD132) or the low-affinity dimeric IL-2R (IL2RB and IL2RG). Interaction with the receptor leads to oligomerization and conformation changes in the IL-2R subunits resulting in downstream signaling starting with phosphorylation of JAK1 and JAK3. In turn, JAK1 and JAK3 phosphorylate the receptor to form a docking site leading to the phosphorylation of several substrates including STAT5. This process leads to activation of several pathways including STAT, phosphoinositide-3-kinase/PI3K and mitogen-activated protein kinase/MAPK pathways. Functions as a T-cell growth factor and can increase NK-cell cytolytic activity as well. Promotes strong proliferation of activated B-cells and subsequently immunoglobulin production. Plays a pivotal role in regulating the adaptive immune system by controlling the survival and proliferation of regulatory T-cells, which are required for the maintenance of immune tolerance. Moreover, participates in the differentiation and homeostasis of effector T-cell subsets, including Th1, Th2, Th17 as well as memory CD8-positive T-cells.
Protein Name Interleukin-2
Il-2
T-Cell Growth Factor
Tcgf
Cellular Localisation Secreted
Alternative Antibody Names Anti-Interleukin-2 antibody
Anti-Il-2 antibody
Anti-T-Cell Growth Factor antibody
Anti-Tcgf antibody
Anti-Il2 antibody
Anti-Il-2 antibody

Information sourced from Uniprot.org

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