| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | IL1RN |
| Gene ID: | 3557 |
| Uniprot ID: | IL1RA_HUMAN |
| Immunogen Region: | 24-177 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 24-177 of human IL1RA (NP_776214.1). |
| Immunogen Sequence: | ICRPSGRKSSKMQAFRIWDV NQKTFYLRNNQLVAGYLQGP NVNLEEKIDVVPIEPHALFL GIHGGKMCLSCVKSGDETRL QLEAVNITDLSENRKQDKRF AFIRSDSGPTTSFESAACPG WFLCTAMEADQPVSLTNMPD EGVMVTKFYFQEDE |
| Tissue Specificity | The intracellular form of IL1RN is predominantly expressed in epithelial cells. |
| Function | Anti-inflammatory antagonist of interleukin-1 family of proinflammatory cytokines such as interleukin-1beta/IL1B and interleukin-1alpha/IL1A. Protects from immune dysregulation and uncontrolled systemic inflammation triggered by IL1 for a range of innate stimulatory agents such as pathogens. |
| Protein Name | Interleukin-1 Receptor Antagonist ProteinIl-1rnIl-1raIrapIcil-1raIl1 InhibitorAnakinra |
| Database Links | Reactome: R-HSA-6783783Reactome: R-HSA-9020702 |
| Cellular Localisation | Isoform 1: SecretedIsoform 2: CytoplasmIsoform 3: CytoplasmIsoform 4: Cytoplasm |
| Alternative Antibody Names | Anti-Interleukin-1 Receptor Antagonist Protein antibodyAnti-Il-1rn antibodyAnti-Il-1ra antibodyAnti-Irap antibodyAnti-Icil-1ra antibodyAnti-Il1 Inhibitor antibodyAnti-Anakinra antibodyAnti-IL1RN antibodyAnti-IL1F3 antibodyAnti-IL1RA antibody |
Information sourced from Uniprot.org