| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: | IL19 |
| Gene ID: | 29949 |
| Uniprot ID: | IL19_HUMAN |
| Immunogen Region: | 1-215 aa |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-215 of human IL19 (NP_715639.1). |
| Immunogen Sequence: | MCTEGAFPHRSACSLPLTHV HTHIHVCVPVLWGSVPRGMK LQCVSLWLLGTILILCSVDN HGLRRCLISTDMHHIEESFQ EIKRAIQAKDTFPNVTILST LETLQIIKPLDVCCVTKNLL AFYVDRVFKDHQEPNPKILR KISSIANSFLYMQKTLRQCQ EQRQCHCRQEATNATRVIHD NYDQLEVHAAAIKSLGELDV FLAWINKNHEVMFSA |
| Function | Cytokine that functions as an anti-inflammatory and proangiogenic factor. Polarizes adaptive immunity to an anti-inflammatory phenotype through induction of T-helper 2 responses by both down-regulation of IFN-gamma and up-regulation of IL4 and IL13. Produced by osteocytes, stimulates granulopoiesis and neutrophil formation. Exerts its biological effect through a receptor complex consisting of a heterodimer of IL20RA and IL20RB. In turn, activates the Janus kinase (JAK) and signal transducer and activator of transcription (STAT) pathway, and importantly, STAT3. |
| Protein Name | Interleukin-19Il-19Melanoma Differentiation-Associated Protein-Like ProteinNg.1 |
| Database Links | Reactome: R-HSA-8854691 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Interleukin-19 antibodyAnti-Il-19 antibodyAnti-Melanoma Differentiation-Associated Protein-Like Protein antibodyAnti-Ng.1 antibodyAnti-IL19 antibodyAnti-ZMDA1 antibody |
Information sourced from Uniprot.org