| Host: | Mouse |
| Applications: | WB |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Mouse monoclonal antibody anti-Interleukin-18-binding protein is suitable for use in Western Blot research applications. |
| Clonality : | Monoclonal |
| Clone ID : | 5C7-D2-G4-B6 |
| Conjugation: | Unconjugated |
| Isotype: | IgG2b |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:400 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | IL18BP |
| Gene ID: | 10068 |
| Uniprot ID: | I18BP_HUMAN |
| Specificity: | This antibody detects endogenous levels of IL18 binding protein and does not cross-react with related proteins. |
| Immunogen: | Purified recombinant human IL18 binding protein protein fragments expressed in E.coli. |
| Post Translational Modifications | N- and O-glycosylated. O-glycosylated with core 1-like and core 2-like glycans. O-glycan heterogeneity at Ser-53: HexHexNAc (major) and Hex2HexNAc2 (minor). N-glycan heterogeneity at Asn-103: Hex5HexNAc4 (minor), dHex1Hex5HexNAc4 (major) and Hex6HexNAc5 (minor).N-glycan at Asn-147: dHex1Hex5HexNAc4. |
| Function | Isoform A binds to IL-18 and inhibits its activity. Functions as an inhibitor of the early TH1 cytokine response. |
| Protein Name | Interleukin-18-Binding Protein Il-18bp Tadekinig-Alfa |
| Database Links | Reactome: R-HSA-9008059 Reactome: R-HSA-9012546 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Interleukin-18-Binding Protein antibody Anti-Il-18bp antibody Anti-Tadekinig-Alfa antibody Anti-IL18BP antibody |
Information sourced from Uniprot.org