Home
Primary Antibodies
Polyclonal Antibodies
Anti-IL18 antibody (STJ192030)

Western blot analysis of lysates from Jarkat cells, primary antibody was diluted at 1:1000, 4°C over night

Anti-IL18 antibody (STJ192030)

SKU:

STJ192030

£46.00 - £226.00

Current Stock:

General Information
Product Properties
Target Information
Additional Info
Warranty Information

Host:	Rabbit
Applications:	WB/IF/ELISA
Reactivity:	Human/Rat/Mouse
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-Interleukin-18 is suitable for use in Western Blot, Immunofluorescence and ELISA research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1 mg/mL
Dilution Range:	WB 1:500-2000 IF 1:100-300 ELISA 1:5000-20000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	IL18
Gene ID:	3606
Uniprot ID:	IL18_HUMAN
Specificity:	IL18 Polyclonal Antibody detects endogenous levels of protein.
Immunogen:	Synthesized peptide derived from part of the human protein

Function	Pro-inflammatory cytokine primarily involved in epithelial barrier repair, polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells and natural killer (NK) cells. Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore.
Protein Name	Interleukin-18 Il-18 Iboctadekin Interferon Gamma-Inducing Factor Ifn-Gamma-Inducing Factor Interleukin-1 Gamma Il-1 Gamma
Database Links	Reactome: R-HSA-448706 Reactome: R-HSA-5620971 Reactome: R-HSA-6783783 Reactome: R-HSA-6785807 Reactome: R-HSA-9012546 Q14116-2 Reactome: R-HSA-9660826
Cellular Localisation	Cytoplasm Secreted The Precursor Is Cytosolic In Response To Inflammasome-Activating Signals Cleaved And Secreted Mature Form Is Secreted And Released In The Extracellular Milieu By Passing Through The Gasdermin-D (Gsdmd) Pore In Contrast The Precursor Form Is Not Released Due To The Presence Of An Acidic Region That Is Proteolytically Removed By Casp1 During Maturation The Secretion Is Dependent On Protein Unfolding And Facilitated By The Cargo Receptor Tmed10
Alternative Antibody Names	Anti-Interleukin-18 antibody Anti-Il-18 antibody Anti-Iboctadekin antibody Anti-Interferon Gamma-Inducing Factor antibody Anti-Ifn-Gamma-Inducing Factor antibody Anti-Interleukin-1 Gamma antibody Anti-Il-1 Gamma antibody Anti-IL18 antibody Anti-IGIF antibody Anti-IL1F4 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

reviews