| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | IL17RE |
| Gene ID: | 132014 |
| Uniprot ID: | I17RE_HUMAN |
| Immunogen Region: | 24-260 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 24-260 of human IL17RE (NP_705613.1). |
| Immunogen Sequence: | AGIGFRHLPHWNTRCPLASH TDDSFTGSSAYIPCRTWWAL FSTKPWCVRVWHCSRCLCQH LLSGGSGLQRGLFHLLVQKS KKSSTFKFYRRHKMPAPAQR KLLPRRHLSEKSHHISIPSP DISHKGLRSKRTQPSDPETW ESLPRLDSQRHGGPEFSFDL LPEARAIRVTISSGPEVSVR LCHQWALECEELSSPYDVQK IVSGGHTVELPYEFLLPCLC IEASYLQEDTVRRKKCP |
| Tissue Specificity | Predominantly expressed in mucosal tissues with high levels in keratinocytes and colon epithelial cells. Very low expression in dermal fibroblasts. Expressed in various tumor cell lines. |
| Function | Specific functional receptor for IL17C. May be signaling through the NF-kappa-B and MAPK pathways. May require TRAF3IP2 /ACT1 for signaling. May be a crucial regulator in innate immunity to bacterial pathogens. Isoform 2 and isoform 4 may be either cytoplasmic inactive or dominant active forms. Isoform 3 and isoform 5 may act as soluble decoy receptors. |
| Protein Name | Interleukin-17 Receptor EIl-17 Receptor EIl-17re |
| Database Links | Reactome: R-HSA-448424 |
| Cellular Localisation | Isoform 1: Cell MembraneSingle-Pass Type I Membrane ProteinIsoform 2: CytoplasmIsoform 3: SecretedIsoform 4: CytoplasmIsoform 5: Secreted |
| Alternative Antibody Names | Anti-Interleukin-17 Receptor E antibodyAnti-Il-17 Receptor E antibodyAnti-Il-17re antibodyAnti-IL17RE antibodyAnti-UNQ3056 antibodyAnti-PRO9877 antibody |
Information sourced from Uniprot.org