| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Interleukin-12 receptor subunit beta-2 (270-350 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000ELISA 1:5000-20000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | IL12RB2 |
| Gene ID: | 3595 |
| Uniprot ID: | I12R2_HUMAN |
| Immunogen Region: | 270-350 aa |
| Specificity: | I12R2 Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: | Synthesized peptide derived from the human protein at the amino acid range 270-350 |
| Post Translational Modifications | On IL12 binding, phosphorylated on C-terminal tyrosine residues by JAK2. Phosphorylation on Tyr-800 is required for STAT4 binding and activation, and for SOCS3 binding. |
| Function | Receptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway. Promotes the proliferation of T-cells as well as NK cells. Induces the promotion of T-cells towards the Th1 phenotype by strongly enhancing IFN-gamma production. |
| Protein Name | Interleukin-12 Receptor Subunit Beta-2Il-12 Receptor Subunit Beta-2Il-12r Subunit Beta-2Il-12r-Beta-2Il-12rb2 |
| Database Links | Reactome: R-HSA-8984722Reactome: R-HSA-9020591 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Interleukin-12 Receptor Subunit Beta-2 antibodyAnti-Il-12 Receptor Subunit Beta-2 antibodyAnti-Il-12r Subunit Beta-2 antibodyAnti-Il-12r-Beta-2 antibodyAnti-Il-12rb2 antibodyAnti-IL12RB2 antibody |
Information sourced from Uniprot.org